摘要
Abstract
Objective To investigate the clinical effect of tripterygium glycosides combined with compound α-keto acid in the treatment of diabetic nephropathy (DN) and its effect on renal interstitial fibrosis and oxidative stress. Methods Totally 93 patients with DN admitted to our hospital from January 2014 to May 2017 were selected and randomly divided into the control group (46 cases) and the treatment group (47 cases). The control group was treated with tripterygium glycosides, while the treatment group was treated with tripterygium glycosides combined with compound α-keto acid. The two groups were treated for 3 months. Results The total effective rate of the treatment group was 93. 62％, which was significantly higher than 78. 26％ of the control group (χ2= 4. 559, P = 0. 033).After treatment, the levels of serum creatinine (SCr), blood urea nitrogen (BUN), cystatin C (CysC), 24 h urinary protein quantification, vascular endothelial growth factor (VEGF), homocysteine (Hcy), transforming growth factor-β1 (TGF-β1), malondialdehyde (MDA) and advanced oxidation protein products (AOPP) in the two groups were lower than those before treatment, and the decrease in the treatment group was more significant (P ＜ 0. 05). While the levels of hepatocyte growth factor (HGF), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) in the two groups were higher than those before treatment, and the increase in the treatment group was more significant (P ＜ 0. 05). There was no significant difference in the incidence rate of adverse reactions between the two groups (χ2= 0. 595, P = 0. 440). Conclusion Tripterygium glycosides combined with compound α-keto acid is effective in the treatment of DN, it can improve renal function, inhibit renal interstitial fibrosis and reduce oxidative stress. It is safe and worthy of clinical promotion.关键词
糖尿病肾病/雷公藤多苷/复方α-酮酸/临床疗效/肾间质纤维化/氧化应激Key words
diabetic nephropathy/tripterygium glycosides/compound α-keto acid/clinical effect/renal interstitial fibrosis/oxidative stress分类
医药卫生
