中国医药科学2018，Vol.8Issue(24)：13-16,4.
血清HMGB-1及PCT对食管癌患者手术后感染病情的评估效果研究
Research on evaluation effect of serum HMGB-1 and PCT on postoperative infection in patients with esophageal cancer
齐晓轩 1黄建伟 1高克峰 1高青 1张凯悦1
作者信息
- 1. 牡丹江医学院附属红旗医院,黑龙江牡丹江 157000
- 折叠
摘要
Abstract
Objective To explore the evaluation effect of serum high mobility groupbox-1 protein (HMGB-1) and procalitonin (PCT) on postoperative infection in patients with esophageal cancer. Methods 136 patients with esophageal cancer who were treated and developed nosocomial infection after radical surgery in our hospital from February 2017 to May 2018 were selected as research objects. The condition of the disease was evaluated according to the APACHE II score.They were divided into the mild group (APACHE II score 10-29, n=32), moderate group (APACHE II score 30-49, n=64) and severe group (APACHE II score 50-71 points, n=40). Within 24 h after admission and 24 h after diagnosis of infection, 5 ml of venous blood was collected and PCT and HMGB-1 were detected. Results The serum HMGB-1 and PCT of 136 patients with esophageal cancer were respectively (22.89±8.31) μg/L and (3.96±1.02) μg/L, which were higher than those before infection. The difference was statistically significant (P < 0.05).There were significant differences in serum HMGB-1 and PCT levels among the mild group, moderate group and severe groups (P < 0.05). The serum HMGB-1 and PCT levels of the moderate group and severe groupwere higher than that of the mild group and the severe group was higher than the moderate group (P < 0.05).Spearman linear correlation analysis showed that serum HMGB-1 (r=0.681) and PCT (r=0.692) levels after infection were positively correlated with APACHE II scores (P < 0.05). Conclusion The detection of serum HMGB-1 and PCT levels can effectively assess the infectiousdegree of patients with esophageal cancer who develop postoperative infection. It has greatimportance for guiding clinical treatment and striving for the best treatment opportunity.关键词
食管癌/术后感染/HMGB-1/PCT/病情Key words
Esophageal cancer/Postoperative infection/HMGB-1/PCT/Condition分类
医药卫生引用本文复制引用
齐晓轩,黄建伟,高克峰,高青,张凯悦..血清HMGB-1及PCT对食管癌患者手术后感染病情的评估效果研究[J].中国医药科学,2018,8(24):13-16,4.
