中国医院用药评价与分析2019，Vol.19Issue(1)：9-13,5.DOI:10.14009/j.issn.1672-2124.2019.01.003
基于网络药理学探究人参治疗心肌缺血的作用机制
Mechanism of Ginseng in Treatment of Myocardial Ischemia Based on Network Pharmacology
摘要
Abstract
OBJECTIVE: To predict into the mechanism of ginseng in treatment of myocardial ischemia based on network pharmacology. METHODS: The chemical structure of ginseng related active ingredients was obtained from the comprehensive database of Chinese herbal medicine. Through the database of active ingredients of Chinese herbal medicine and the database of therapeutic targets, the active ingredient targets of ginseng were screened and the data set of active ingredient targets of ginseng was established. The target set of myocardial ischemia was established by screening the target of myocardial ischemia through Mendelian genetic database. The interaction targets of ginseng and myocardial ischemia were constructed by protein-protein interaction network. Cytoscape software was used to construct the "component-targeted disease-related" interaction network graph, and the gene ontology (GO) enrichment analysis and the biological pathway enrichment analysis based on Kyoto encyclopedia of genes and genomes (KEGG) were conducted to study the mechanism of ginseng in treatment of myocardial ischemia. RESULTS: Fifty-nine active ingredients, 40 interactive proteins and 15 protein targets directly affected by myocardial ischemia in ginseng were screened. There were 24 GO analysis items, including negative regulation of calcium ion transport, negative regulation of exogenous apoptosis signal pathway, active oxygen metabolism regulation and nitric oxide biosynthesis process. There were 43 KEGG signaling pathways, including thyroid hormone signaling pathway, sphingolipid signaling pathway, FcεRI signaling pathway, vascular endothelial growth factor signaling pathway and tumor necrosis factor signaling pathway. CONCLUSIONS: This study preliminarily revealed the multi-dimensional regulatory network of ginseng in treatment of myocardial ischemia through network pharmacology, which can provide theoretical basis for its clinical application.关键词
网络药理学/人参/心肌缺血/作用机制Key words
Network pharmacology/Ginseng/Myocardial ischemia/Mechanism分类
医药卫生引用本文复制引用
陈兴,张璐,吴诗华,王涛,高思佳,王丹,赵艳玲..基于网络药理学探究人参治疗心肌缺血的作用机制[J].中国医院用药评价与分析,2019,19(1):9-13,5.基金项目
卫生专业重大项目 (No.AWS16J018) （No.AWS16J018）
