中国医院用药评价与分析2019，Vol.19Issue(1)：34-35,38,3.DOI:10.14009/j.issn.1672-2124.2019.01.012
多西他赛、洛铂联合放疗治疗中晚期食管癌的疗效观察
Observation on Efficacy of Docetaxe and Lobaplatin Combined with Radiotherapy in Treatment of Middle and Advanced Esophageal Cancer
赵彦波 1杨岩1
作者信息
- 1. 抚顺矿务局总医院放疗科, 辽宁 抚顺 113008
- 折叠
摘要
Abstract
OBJECTIVE: To probe into the clinical efficacy of docetaxel and lobaplatin combined with radiotherapy in treatment of middle and advanced esophageal cancer. METHOD: 64 patients with esophageal cancer admitted into General Hospital of Fushun Mining Bureau from Feb. 2013 to Feb. 2015 were retrospectively selected and divided into observation group (33 cases) and control group (31 cases) according to different therapeutic regimens. The control group was given three dimensional conformal radiation therapy alone, while the observation group was given docetaxel and lobaplatin for chemotherapy based on the control group. Differences in incidences of adverse drug reactions between two groups were compared; in 3-year follow-up, the survival rates of patients in 1, 2 and 3 years were observed. RESULTS: The incidence of nausea and vomiting of observation group was 57.6％ (19/33), which was significantly higher than that of the control group (45.2％, 14/31), with statistically significant difference (P＜0.05), there was no significant difference in incidence of other adverse drug reactions (P＞0.05); the survival rates of observation group in 1, 2 and 3 years were significantly higher than those of the control group, with statistically significant differences (P＜0.05). CONCLUSIONS: The combination of docetaxel and lobaplatin with radiotherapy in treatment of middle and advanced esophageal cancer can effectively prolong patients' lifetime.关键词
多西他赛/洛铂/放疗/中晚期食管癌Key words
Docetaxe/Lobaplatin/Radiotherapy/Middle and advanced esophageal cancer分类
医药卫生引用本文复制引用
赵彦波,杨岩..多西他赛、洛铂联合放疗治疗中晚期食管癌的疗效观察[J].中国医院用药评价与分析,2019,19(1):34-35,38,3.
