摘要
Abstract
OBJECTIVE: To probe into the effects of compound Kushen injection assisted concurrent chemoradiotherapy on levels of matrix metalloproteinase-2 (MMP-2), bone alkaline phosphatase (B-ALP) and vascular endothelial growth factor (VEGF) in peripheral blood of patients with locally advanced nasopharyngeal carcinoma. METHODS: 60 patients with locally advanced nasopharyngeal carcinoma admitted into Fengcheng People's Hospital from Nov. 2015 to Feb. 2018 were selected and divided into observation group and control group via random number table, with 30 cases in each. The control group was given concurrent chemoradiotherapy, while the observation group was treated with compound Kushen injection based on the control group. The clinical efficacy, T cell subsets (CD4+, CD8+ and CD4+/CD8+) levels, serum MMP-2, B-ALP and VEGF levels of both groups before and after treatment were observed. RESULTS: The total effective rate of observation group was 80.00％ (24/30), which was significantly higher than that of the control group (53.33％, 16/30), with statistically significant difference (P＜0.05); after treatment, the CD8+ level of observation group was significantly lower than that of the control group, while the CD4+ and CD4+/CD8+ levels of observation group were significantly higher, with statistically significant differences (P＜0.05); after treatment, the serum MMP-2, B-ALP and VEGF levels of both groups were significantly lower than those of before treatment, and those of observation group were significantly lower than the control group, with statistically significant differences (P＜0.05). CONCLUSIONS: Compound Kushen injection assisted concurrent chemoradiotherapy can effectively reduce the MMP-2, B-ALP and VEGF levels in peripheral blood of patients with locally advanced nasopharyngeal carcinoma, regulate immunologic function and improve clinical efficacy.关键词
复方苦参注射液/同期放化疗/局部晚期鼻咽癌/MMP-2/B-ALP/VEGFKey words
Compound Kushen injection/Concurrent chemoradiotherapy/Locally advanced nasopharyngeal carcinoma/MMP-2/B-ALP/VEGF分类
医药卫生
