摘要
Abstract
OBJECTIVE: To probe into the clinical efficacy of Shenkang injection combined with alprostadil injection in treatment of chronic renal failure. METHODS: 107 patients with chronic renal failure admitted into Xiangyang No.1 People's Hospital from Jul. 2014 to Jul. 2017 were selected and divided into observation group (54 cases) and control group (53 cases) via random number table. The control group was treated with alprostadil injection, while the observation group was given Shenkang injection combined with alprostadil injection. Differences in renal indices [24 h urine protein quantitation, blood urea nitrogen (BUN), creatinine clearance rate (Ccr) and serum creatinine (SCr) ], blood lipid indices [triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), apolipoprotein-Al (Apo-Al) and apolipoprotein-B100 (Apo-B100) ], immunological indices [circulating immune complex (CIC), CD3+, CD4+, CD8+ and CD4+/CD8+] and liver function indices [aspartate amino transferase (AST), alanine aminotransferase (ALT) ] between two groups before and after treatment were compared. RESULTS: After treatment, the 24 h urinary protein quantitation, BUN and SCr levels of observation group were significantly lower than those of the control group, while the Ccr level of observation group was significantly higher, with statistically significant differences (P＜0.05); the TG, TC and Apo-B100 levels of observation group were significantly lower than those of the control group, while the HDL-C and Apo-Al levels of observation group were significantly higher, with statistically significant differences (P＜0.05); the CIC and CD8+ levels of observation group were significantly lower than those of the control group, while the CD3+, CD4+ and CD4+/CD8+ levels of observation group were significantly higher, with statistically significant differences (P＜0.05); there were no statistical differences in AST and ALT levels between two groups before and after treatment (P＞0.05). CONCLUSIONS: The combination of Shenkang injection and alprostadil injection in treatment of chronic renal failure can effectively improve patients' renal function, reduce blood lipid level and CIC, with no significant effect on liver function.关键词
前列地尔/肾康注射液/慢性肾衰竭Key words
Alprostadil/Shenkang injection/Chronic renal failure分类
医药卫生
