中国医院用药评价与分析2019，Vol.19Issue(1)：87-89,3.DOI:10.14009/j.issn.1672-2124.2019.01.031
氟喹诺酮类抗菌药物的使用与耐亚胺培南鲍曼不动杆菌产生的相关性分析
Correlation Analysis Between Application of Fluoroquinolone Antibiotics and Production of Imipenem-Resistant Acinetobacter Baumannii
摘要
Abstract
OBJECTIVE: To probe into the application of fluoroquinolone antibiotics and production of imipenem-resistant Acinetobacter baumannii, so as to optimize the application in clinic. METHODS: The drug resistance rate of Acinetobacter baumannii (isolated from the specimens sent by adult inpatients) to imipenem, DDDs of fluoroquinolones and its proportion in total DDDs of antibiotics were calculated in Yichun Hospital of Integrated Traditional Chinese and Western Medicine from Jun. 2015 to Dec. 2017. Pearson correlation analysis with SPSS 16.0 software was used to analyze the correlation. RESULTS: The resistance rate of Acinetobacter baumannii to imipenem was positively correlated with the DDDs of moxifloxacin and its proportion in total DDDs of antibiotics (r=0.944, P=0.016; r=0.934, P=0.020). There was no correlation between the DDDs of levofloxacin used and its proportion in total DDDs of antibiotics and the DDDs of fluoroquinolone used and its proportion in total DDDs of antibiotics. CONCLUSIONS: The use of moxifloxacin can induce the production of Acinetobacter baumannii resistant to imipenem, and levofloxacin is preferred when clinical use of fluoroquinolone antibiotics is required.关键词
鲍曼不动杆菌/亚胺培南/氟喹诺酮类抗菌药物/DDDsKey words
Acinetobacter baumanii/Imipenem/Fluoroquinolone antibiotics/DDDs分类
医药卫生引用本文复制引用
游永龙,陈虎,邓国泉..氟喹诺酮类抗菌药物的使用与耐亚胺培南鲍曼不动杆菌产生的相关性分析[J].中国医院用药评价与分析,2019,19(1):87-89,3.基金项目
江西省宜春市科技计划项目 (No.JXYC2016KSB007) （No.JXYC2016KSB007）
