摘要
Abstract
OBJECTIVE: To provide basis for the rational application of clinical antibiotics in orthopedics. METHODS: In 2017, the distribution, composition and drug resistance of common pathogens in Shanghai Kaiyuan Orthopedics Hospital (hereinafter referred to as "our hospital") were statistically analyzed by retrospective analysis. RESULTS: A total of 470 pathogens were detected, mainly from wound secretions, puncture fluid and cerebrospinal fluid, including 242 Gram-negative bacteria (51.5％), 210 Gram-positive bacteria (44.7％), and 18 fungi (3.8％). The top 6 strains were Staphylococcus aureus (67 strains, 14.3％), Escherichia coli (59 strains, 12.6％), and Staphylococcus epidermidis (52 strains, 11.1％). Lactobacillus (49 strains, 10.4％), Pseudomonas aeruginosa (36 strains, 7.7％) and Acinetobacter baumannii (34 strains, 7.2％). Gram-positive bacteria detected in our hospital were mainly Staphylococcus aureus and Staphylococcus epidermidis. No strains resistant to vancomycin or linezolid were found, and the resistance to teicoplanin was low. Gram-negative bacteria were mainly Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, which had a certain degree of resistance to different varieties of antibiotics, including Klebsiella pneumoniae, the resistance rate of bacteria to carbapenem antibiotics was＞30％. CONCLUSIONS: The pathogens in our hospital are mainly Gram-negative bacteria, slightly more than the Gram-positive bacteria. The overall drug resistance is not optimistic. The monitoring of drug resistance of pathogens should be strengthened to improve the rational application level of antibiotics.关键词
细菌/耐药性监测/抗菌药物/合理用药Key words
Bacteria/Monitoring of drug resistance/Antibiotics/Rational drug use分类
医药卫生
