摘要
Abstract
OBJECTIVE: To probe into the clinical efficacy of different administration methods of glucocorticoids in treatment of acute exacerbation of chronic obstructive pulmonary disease. METHODS: 150 patients with chronic obstructive pulmonary disease admitted into Jingzhou Chest Hospital from Feb. 2016 to Jun. 2018 were extracted to be divided into inhalation group (budesonide suspension nebulized inhalation), oral group (prednisone tablets orally) and intravenous group (methylprednisolone intravenous infusion) via the random throwing methods, with 50 cases in each. The arterial blood gas analysis indexes [arterial partial pressure oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2) ], pulmonary function indexes [1 s forced expiratory volume (FEV1), predicted percentage of FEV1 (FEV1％ pred) and occupational vital capacity percentage of FEV1 (FEV1/FVC) ], serum inflammatory factors [C-reactive protein (CRP), tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) ] levels and the occurrence of adverse drug reactions of three groups were observed. RESULTS: After treatment, the levels of FEV1, FEV1％ pred, FEV1/FVC and PaO2 in the three groups were significantly higher than those before treatment, and the levels of PaCO2 were significantly lower, with statistically significant differences (P＜0.05). Patients in the inhalation group had significantly lower FEV1, FEV1％ pred and FEV1/FVC than those in the oral group and the intravenous group, with statistically significant differences (P＜0.05). After treatment, the serum levels of CRP, TNF-α and IL-6 in three groups were significantly lower than those before treatment, and the differences were statistically significant (P＜0.05), while the differences among three groups were not statistically significant (P＞0.05). The incidence of adverse drug reactions in three groups was 14.0％ (7/50) 、24.0％ (12/50) and 36.0％ (18/50), respectively. The incidence of adverse drug reactions in the inhalation group was significantly lower than that in the intravenous group, and the difference was statistically significant (P＜0.05). CONCLUSIONS: Intravenous, oral and aerosol inhaled corticosteroids can significantly improve the condition of patients with acute exacerbation of chronic obstructive pulmonary disease, and the effect of intravenous administration is the best, and the side effects of aerosol inhalation are the least.关键词
慢性阻塞性肺疾病急性加重期/糖皮质激素/不同给药方式Key words
Chronic obstructive pulmonary disease/Glucocorticoids/Different administration methods分类
医药卫生
