摘要
Abstract
OBJECTIVE: To probe into the efficacy of hemocoagulase for injection combined with somatostatin and pantoprazole in treatment of upper gastrointestinal hemorrhage. METHODS: 129 patients with upper gastrointestinal hemorrhage admitted into People's Hospital of Fuyang from Jan. 2016 to Mar. 2018 were selected and divided into group A, group B and group C via random number table, with 43 cases in each group. Group A was given hemocoagulase for injection combined with somatostatin and pantoprazole, group B was given somatostatin combined with pantoprazole, group C was given hemocoagulase for injection combined with pantoprazole. Differences in clinical efficacy, time of bleeding stopping, hospital stays, volume of blood transfusion, amount of bleeding, frequency of bleeding, frequency of tarry stool, blood pressure, heart rate, pH of gastric juice, incidences of adverse drug reactions and recovery of mucous membrane among three groups were compared. RESULTS: At 72 h after treatment, the total effective rate of group A was 97.67％ (42/43), which was significantly higher than that of group B (83.72％, 36/43) and group C (81.40％, 35/43), with statistically significant differences (P＜0.05); and there was no statistical significance in difference of total effective rates between group B and group C (P＞0.05). After treatment, the time of bleeding stopping and hospital stays of patients in group A were significantly shorter than those in group B and C, and the volume of blood transfusion, amount of bleeding, frequency of bleeding and frequency of tarry stool were significantly less than those in group B and C, with statistically significant differences (P＜0.05); and there was no significant difference in the above indexes between group B and group C (P＞0.05). There was no significant difference in blood pressure (systolic blood pressure, diastolic blood pressure) and heart rate among the three groups before and after treatment (P＞0.05). After treatment, the pH of gastric juice in group A was significantly higher than that in group B and C, and the difference was statistically significant (P＜0.05). The incidence of adverse drug reactions in group A, B and C were 11.6％ (5/43), 14.0％ (6/43) and 7.0％ (3/43), respectively, and the difference was not statistically significant (P＞0.05). After treatment, the endoscopic recovery of mucosa in group A was significantly better than that in group B and C. CONCLUSIONS: The efficacy of hemocoagulase for injection combined with somatostatin and pantoprazole in treatment of upper gastrointestinal hemorrhage is significant, which can effectively control the acute bleeding of patients, save time for rescue and improve the prognosis of patients.关键词
泮托拉唑/注射用白眉蛇毒血凝酶/生长抑素/上消化道出血Key words
Pantoprazole/Hemocoagulase for injection/Somatostatin/Upper gastrointestinal hemorrhage分类
医药卫生
