摘要
Abstract
OBJECTIVE: To compare the efficacy between omeprazole, esomeprazole and pantoprazole in treatment of upper gastrointestinal bleeding. METHODS: 180 patients with upper gastrointestinal bleeding admitted into Guangzhou Zengcheng District People's Hospital from Jan. 2015 to Jan. 2017 were selected and divided into group A, group B and group C via random number table, with 60 cases in each group. Group A was given omeprazole injection for intravenous drip, group B was given esomeprazole injection for intravenous drip, group C was given pantoprazole injection for intravenous drip. Differences in frequency of haematemesis, frequency of tarry stool, amount of bleeding, pH of fasting gastric juice and incidences of adverse drug reactions among three groups were compared, and cost-effectiveness analysis was conducted. RESULTS: At the 1 st, 3 rd and 5 th day, there were no statistical significance in differences in frequencies of haematemesis and tarry stool (P＞0.05); at the 3 rd and 5 th day, the amounts of bleeding of three groups were significantly less than that of the 1 st day, the amounts of bleeding group A at the 1 st and 3 rd day were significantly more than those of group B and group C, with statistically significant differences (P＜0.05); there was no statistical significance in difference in the amount of bleeding between group B and group C (P＞0.05). After treatment, the pH of fasting gastric juice of three groups were significantly better than those of before treatment, the pH of fasting gastric juice of group A was significantly lower than group B and group C, with statistically significant differences (P＜0.05); there was no statistical significance in difference in pH of fasting gastric juice between group B and group C (P＞0.05). There was no statistical significance in difference in incidences of adverse drug reactions among three groups (P＞0.05). The cost-effectiveness of group C was the lowest in three groups. CONCLUSIONS: The efficacy of omeprazole, esomeprazole and pantoprazole in treatment of upper gastrointestinal bleeding are remarkable, of which esomeprazole is better in inhibiting gastric acid secretion, with shorter time of bleeding stopping and fewer adverse drug reactions, which can be used as the first choice for the treatment of upper gastrointestinal bleeding; while pantoprazole has the highest economic benefit.关键词
奥美拉唑/埃索美拉唑/泮托拉唑/上消化道出血Key words
Omeprazole/Esomeprazole/Pantoprazole/Upper gastrointestinal bleeding分类
医药卫生
