摘要
Abstract
OBJECTIVE: To probe into the effects of clopidogrel combined with atorvastatin on fibrinolysis status and cardiac function in patients with angina pectoris of coronary heart disease (CHD). METHODS: Totally 116 patients with angina pectoris of CHD admitted into Henan Tanghe County People's Hospital from Oct. 2016 to Oct. 2017 were extracted to be divided into observation group and control group via the random number table, with 58 cases in each group. Patients in the control group were given conventional drug therapy, while the observation group received clopidogrel and atorvastatin on the basis of the control group. The clinical efficacy, number and duration of angina attacks, tissue plasminogen activator inhibitor 1 (tPAI-1), soluble E-selectin (sE-selectin), ejection fraction (EF), cardiac index (CI) before and after treatment and adverse drug reactions were observed. RESULTS: The total effective rate of the observation group was 93.10％ (54/58), significantly higher than that of the control group (77.59％, 45/58), with statistically significant difference (P＜0.05). After treatment, the number and duration of angina attacks in the observation group were significantly better than those in the control group, with statistically significant differences (P＜0.05). After treatment, the tPAI-1 and sE-selectin levels in the observation group were significantly lower than those in the control group, and the EF and CI levels were significantly higher than those in the control group, with statistically significant differences (P＜0.05). The incidence of adverse drug reactions in the observation group and the control group was 5.17％ (3/58) and 8.62％ (5/58), respectively, with no statistically significant difference (P＞0.05). CONCLUSIONS: The efficacy of clopidogrel combined with atorvastatin in treatment of angina pectoris of CHD is remarkable, which can correct the symptoms of angina pectoris, help to regulate the state of fibrinolysis and improve the heart function with higher safety.关键词
冠心病心绞痛/氯吡格雷/阿托伐他汀/纤溶状态/心功能Key words
Angina pectoris of coronary heart disease/Clopidogrel/Atorvastatin/Fibrinolysis status/Cardiac function分类
医药卫生
