摘要
Abstract
OBJECTIVE: From the perspective of evidence-based medicine, to systematically review the efficacy and safety of Kang'ai injection combined with chemotherapy in treatment of gastric cancer, so as to provide references for clinical medication. METHODS: Randomized controlled trials (the observation group was given Kang'ai injection combined with systematic chemotherapy, the control group was given systematic chemotherapy alone) on Kang'ai injection combined with chemotherapy in treatment of gastric cancer during 2005-2015 were retrieved from CNKI, PubMed and Wanfang, data were submitted and Meta-analysis was conducted according to the Cochrane evaluation manual. RESULTS: A total of 16 studies were involved, results of Meta-analysis indicated that the effects of Kang'ai injection combined with chemotherapy in improving living quality (P＜0.000 01), increasing the effective rate of chemotherapy (P＜0.000 01), reducing incidence of white blood cell count reduction (P＜0.000 01), reducing incidences of gastrointestinal reaction (P＜0.000 01) and liver injury (P=0.002) were significantly better than those of chemotherapy alone; there was no statistical significance in difference in reducing the incidence of renal injury between two therapeutic regimens (P=0.15). CONCLUSIONS: Based on present clinical evidence, Kang'ai injection combined with chemotherapy in treatment of gastric cancer can improve the effective rate of chemotherapy and quality of life, reduce part of adverse drug reactions; however, due to the small number of involved studies, the above conclusions should to be treated with caution, which need further verification by high quality, long-term and large-sample trials.关键词
康艾注射液/化疗/胃癌/Meta分析Key words
Kang'ai injection/Chemotherapy/Gastric cancer/Meta analysis分类
医药卫生
