中国真菌学杂志2019，Vol.14Issue(2)：83-89,7.
飞行质谱鉴定临床分离真菌准确度的Meta分析
Mata analysis of accuracy of clinically isolated fungi by flight mass spectrometry
摘要
Abstract
Objective To determine the accuracy of clinical isolates based on evidence-based systematic evaluation of flight mass spectrometry and compare it with the accuracy of conventional methods.Methods The main English databases PubMed,Cochrane,Web of Science,and Chinese database CBM,Wanfang,Weipu,and HowNet database were searched for the original literatures of clinical isolates being identified by flight mass spectrometry.Results After screening,19articles(6609strains)were included.The results of meta-analysis showed that the correct rate of lidentification fungi to species was 0.9368(95％ CI=0.9091-0.9598)by flight mass spectrometry.The correct rate of lidentification fungi to species was 0. 9104(95％CI=0.8874-0.9340)by clinical routine methods.Subgroup analysis of the results,including:strain type,research type,sample processing method,gold standard detection range,identification threshold,etc..Sensitivity analysis showed stable and reliable results.Begg and Egger's results indicated that there was no publication bias in the identification of fungi by flight mass spectrometry,and conventional methods hadidentified a certain publication bias.Conclusion Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry(MALDI-TOF MS)method is a reliable alternative to clinical routine methods for identifying clinical pathogenic fungi with high accuracy.关键词
飞行质谱/真菌/鉴定/常规方法Key words
MALDI-TOF MS/fungus/identification/conventional method分类
医药卫生引用本文复制引用
余甜,林赋桂,胡立冬,李可可,陈晓青,谢跃,时文静,魏莲花..飞行质谱鉴定临床分离真菌准确度的Meta分析[J].中国真菌学杂志,2019,14(2):83-89,7.基金项目
甘肃省卫生行业科研计划(No.GSWST2012-04) （No.GSWST2012-04）
