针灸临床杂志2019，Vol.35Issue(2)：80-83,4.
针刺调控脑缺血再灌注损伤后内质网应激机制的研究进展
Research Advances in Acupuncture Regulating Endoplasmic Reticulum Stress after CIRI
摘要
Abstract
Cerebral ischemia-reperfusion injury ( CIRI) refers to the secondary damage caused by brain tissue and nerve function after the blood supply of ischemic brain tissue is restored. Endoplasmic reticulum stress ( ERS) is a phenomenon in which a large number of errors and unfolded proteins accumulate in the endoplasmic reticulum after being stimulated by external stress. Studies have shown that CIRI can induce ERS, and ERS plays a key role in the pathological process of CIRI. On one hand, ERS can moderately activate unfolded protein response ( UPR) after cerebral ischemia-reperfusion ( CIR), promote endoplasmic reticulum to treat misfolded or unfolded proteins, and protect damaged nerve cells; on the other hand, long-lasting and vigorous UPR will further activate the programmed cell death pathway, induce autophagy and apoptosis. Acupuncture has certain effects on ERS induced by CIR in rats, as well as on autophagy and neuronal apoptosis induced by excessive ERS. This study summarized the research progress of acupuncture on the mechanism of ERS after CIRI, thus to provide a scientific basis for clinical application of acupuncture preventing ischemic stroke.关键词
脑缺血再灌注损伤/内质网应激/未折叠蛋白反应/针刺Key words
Cerebral ischemia-reperfusion injury/Endoplasmic reticulum stress/Unfolded protein response/Acupuncture分类
医药卫生引用本文复制引用
孙晓伟,金弘,李洪涛,王新宇,孙忠人,刘昊,王博,张菶,刘丹,刘勇,陈英华..针刺调控脑缺血再灌注损伤后内质网应激机制的研究进展[J].针灸临床杂志,2019,35(2):80-83,4.基金项目
国家自然科学基金项目,编号:81503669,81804168 （）
黑龙江省自然基金项目,编号:H2015031 （）
黑龙江省博士后资助项目,编号:LHB-Z12248 （）
哈尔滨市科技创新人才基金项目,编号:2014RFQGJ054 （）
黑龙江中医药大学"优秀创新人才支持计划"科研项目,编号:2018RCD11. （）
