中国现代医生2019，Vol.57Issue(10)：12-16,5.
西格列汀对初发2型糖尿病患者颈动脉内膜中层厚度及hs-CRP与IL-6的影响
Effect of sitagliptin on carotid intima-media thickness and hs-CRP and IL-6 in the patients with newly diagnosed type 2 diabetes mellitus
摘要
Abstract
Objective To observe the effect of sitagliptin on carotid intima-media thickness (c-IMT) and serum hs-CRP and IL-6 levels in the patients with newly diagnosed type 2 diabetes mellitus. Methods 65 patients with newly diagnosed type 2 diabetes mellitus who were admitted to the outpatient clinic and were hospitalized in our hospital were selected. They were randomly divided into sitagliptin phosphate tablet group (experimental group) with 35 cases and metformin hydrochloride tablet group (control group) with 30 cases. All patients were given health education about diabetes, diet guidance and exercise. All patients were given drawing of venous blood at a fasting condition ≥10 h before treatment and 6 months after treatment to determine the following indicators: FPG, 2 hPG, hs-CRP, IL-6, TC, TG, HDL-c, LDL-c, HbA1 c, hs-CRP, IL-6, etc, and c-IMT was determined. Results There was no statistically significant difference in blood glucose, blood lipids, inflammation index and c-IMT between the two groups before treatment (P>0.05); after treatment, FPG, 2 hPG and HbA1 c were significantly lower than those before treatment in both groups, and the difference was statistically significant (P<0.01). There were statistically significant differences in FPG and HbA1 c between the two groups (P<0.01). There was no statistically significant difference in 2-hour postprandial blood glucose between groups (P>0.05). The c-IMT, hs-CRP and IL-6 levels in the experimental group after treatment were significantly lower than those before treatment, and the differences were statistically significant (P<0.05). There was no significant change in c-IMT in control group after treatment (P>0.05). hs-CRP and IL-6 had a decreasing trend compared with those before treatment, and the difference was not statistically significant (P>0.05). There were statistically significant differences in c-IMT, hs-CRP and IL-6 between the two groups after treatment (P<0.05). Spearman linear correlation analysis: c-IMT was positively correlated with hs-CRP levels and IL-6 (r=0.6585, P=0.000; r=0.571, P=0.000). There was no significant correlation between fasting blood glucose and glycosylated hemoglobin (P>0.05). Conclusion The DPP-4 inhibitor of sitagliptin has a clear hypoglycemic effect and can reduce c-IMT, hs-CRP and IL-6. The anti-inflammatory effects besides hypoglycemic effect may be involved in the reduction of atherosclerosis in the patients with diabetes mellitus.关键词
西格列汀/2型糖尿病/颈动脉内膜中层厚度/白细胞介素6/高敏C反应蛋白Key words
Sitagliptin/Type 2 diabetes melitus/Carotid intima-media thickness (c-IMT)/IL-6/hs-CRP分类
医药卫生引用本文复制引用
曾文平,熊艳华,黄敬垣,沈世恩,唐礼江..西格列汀对初发2型糖尿病患者颈动脉内膜中层厚度及hs-CRP与IL-6的影响[J].中国现代医生,2019,57(10):12-16,5.基金项目
浙江省医药卫生科技计划项目(2014KYB002) （2014KYB002）
