中国现代中药2019，Vol.21Issue(1)：54-61,8.DOI:10.13313/j.issn.1673-4890.20180530004
人参全草免疫调节作用研究
Studies on the Immunoregulation of Lin-Xia-Shan-Shen in Mice
摘要
Abstract
Objective: To investigate the immune enhancement effect of the whole plant of ginseng in mice, take Lin-Xia-Shan Shen as an example. Methods: The spleen lymphocyte transformation experiment induced by Con A, the delayed type hypersensitivity (DTH) reaction induced by DNFB, the dectection of antibody-producing, and the determination of serum hemolysin experiments were carried out with the Kunming mice. Furthermore, the carbon clearance test, the phagocytosis effect of macrophages with chicken red blood cell experiments, and the determination of natural killer cell activity were also carried out in order to explore the immunoregulation effect of Lin-Xia-Shan-Shen. Results: There was no significant effect on the thymus index and spleen index of the experimental animals treated with Lin-Xia-Shan-Shen. The promotion effect on DTH reaction induced by DNFB experimental dose of mountain cultivated ginseng whole plant had no significant effect on the f were also not observed. The mice treated with middle and high doses of Lin-Xia-Shan-Shen possessed potent proliferation effect on the spleen lymphocyte in mice induced by Con A (P ＜ 0. 01). low and medium doses of mountain cultivated ginseng whole plant significantly increased The number cells of antibody and the accumulation value of anti-body in serum was increased significantly in the groups treated with low and middle dose of Lin-Xia-Shan-Shen (P ＜ 0. 01). Furthermore, the clearance ability of carbon particle was enhanced significantly in the low dose group (P ＜ 0. 01). However, the phagocytosis ability of macrophages, and the activity of NK cells were not increased obviously in all groups. Conclusion: The whole plant of Lin-Xia-Shan-Shen has a certain role in adjust immunity in mice.关键词
人参全草/林下山参/免疫调节Key words
whole plant of ginseng/Lin-Xia-Shan-Shen/immunoregulation分类
医药卫生引用本文复制引用
任国庆,邹晓峰,韩亚男,窦德强..人参全草免疫调节作用研究[J].中国现代中药,2019,21(1):54-61,8.基金项目
国家自然科学基金(81773858) （81773858）
