中国现代中药2019，Vol.21Issue(2)：176-181,6.DOI:10.13313/j.issn.1673-4890.20180621003
鹿茸-山药药对补肾壮阳作用研究
Study on Effect of Antler-Chinese Yam for Invigorating Kidney Yang
摘要
Abstract
Objective:To study the effects of Antler-Chinese yam on kidney yang deficiency rat.Methods:Ninety male rats were randomly divided into blank control group, model control group[injection of hydrocortisone 2.5 mg· (100 g)-1], traditional Chinese medicine control group (0.6 g·kg-1), western medicine control group (testosterone propionate, 10 mg·kg-1), high dose group of Antler-Chinese yam (1.8 g raw drug·kg-1), and middle dose group (0.9 g raw drug·kg-1), low dose group (0.45 g raw drug·kg-1), antler group (0.4 g raw drug·kg-1) and yam group (1.4 g raw drug·kg-1).The influence of each samples on the body weight, serum hormone level and sex organs of hydrocortisone induced Yang deficiency rats were measured.Results:Compared with the blank group, the body weight, serum levels of cAMP and cAMP/cGMP, T, FSH, LH, GnRH and CORT in the model group decreased significantly (P<0.05 or P<0.01), and the prostate coefficient, levator ani muscle and seminal vesicle coefficient decreased significantly (P<0.05).Compared with the model group, the levels of serum cAMP, cAMP/cGMP, T, FSH and prostate coefficient were significantly increased in the Chinese medicine positive group (P<0.05), FSH, LH, coefficient of levator ani muscle and seminal vesicle were significantly increased in the western medicine positive group (P<0.05), T, CORT, GnRH levels in the pilose antler group were significantly increased (P<0.05), and FSH levels in the yam group were significantly increased (P<0.05).The levels of cAMP, cAMP/cGMP, FSH, LH, coefficient of prostate coefficient, levator ani muscle and seminal vesicle in Antler-Chinese yam high dose group were increased (P<0.05), while the body weight and LH levels in Lushan low dose group were significantly increased (P<0.05).Conclusion:The Antler-Chinese yam has the effect of invigorating kidney yang, which may be the synergistic effect of the two drugs to regulate the pituitary-gonadal axis function by increasing the content of cAMP, and improve the level of FSH, LH and the coefficient of gonadal gland.关键词
鹿茸/山药/药对/补肾壮阳Key words
antler/Chinese yam/drug pair/invigorating kidney yang分类
医药卫生引用本文复制引用
李晶峰,边学峰,牛晓晖,孙佳明,孔庆国,张辉..鹿茸-山药药对补肾壮阳作用研究[J].中国现代中药,2019,21(2):176-181,6.基金项目
吉林省科技厅重大科技攻关专项 (20140203015YY) （20140203015YY）
吉林省中医药科技项目 (2017026) （2017026）
吉林省科技攻关项目 (20160209006YY) （20160209006YY）
