中国现代中药2019，Vol.21Issue(2)：208-212,221,6.DOI:10.13313/j.issn.1673-4890.20180807001
Box-Behnken响应面法优选心痛宁胶囊的水提工艺
Optimization of Water Extraction Process of Xintongning Capsule by Box-Behnken Response Surface Method
摘要
Abstract
Objective:To optimize the water extraction process of Xintongning capsule by Box-Behnken response surface method.Methods:On the basis of single factor test results, salvianolic acid B content, total polysaccharide content and extract yield were evaluated, extraction times, extraction time, soaking time and the amount of water added to the water extraction process were selected as the main factors.Box-Behnken response surface method was used to design the experiment.The optimal water extraction process was obtained by fitting the results of quadratic polynomial model.Results:The optimal water extraction process was as follows:11 times of water, soaking for 130 mins, and then reflux extraction for 3 times, 60 mins each time.Conclusion:The water extraction process of Xintongning capsule established by Box-Behnken response surface method is stable and feasible, which provides a theoretical basis for the subsequent industrial production.关键词
心痛宁胶囊/丹酚酸B/总多糖/Box-Behnken响应面法Key words
Xintongning capsule/salvianolic acid B/total polysaccharide/Box-Behnken response surface method分类
医药卫生引用本文复制引用
刘怡,如扎·哈布都拉,李露,王萍,孟瑶,依孜提·帕力哈提,张丽娟,聂继红..Box-Behnken响应面法优选心痛宁胶囊的水提工艺[J].中国现代中药,2019,21(2):208-212,221,6.基金项目
新疆维吾尔自治区科技支疆项目 (指令性) (201191167) （指令性）
