实用肝脏病杂志2019，Vol.22Issue(4)：537-540,4.DOI:10.3969/j.issn.1672-5069.2019.04.022
自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征:巴黎标准诊断中国患者灵敏度低
Autoimmune hepatitis-primary biliary cholangitis overlap syndrome:poor diagnostic sensitivity of Paris' criteria in Chinese patients
张骏飞 1许何明 1宋海燕 1董静 1潘劲劲 1陈照林 1徐军 2陈从新 3刘波1
作者信息
- 1. 230031合肥市 解放军第901医院感染病科
- 2. 230031合肥市 解放军第901医院病理科
- 3. 合肥京东方医院消化肝病科
- 折叠
摘要
Abstract
Objective The aim of this study was to investigate diagnostic performance of Paris criteria in Chinese patients with autoimmune hepatitis/primary biliary cholangitis overlap syndrome（AIH/PBC OS） . Methods We retrospectively analyzed the clinical data of 24 patients with PBC and 16 with AIH/PBC OS diagnosed based on Paris' criteria， and 14 patients with PBC underwent liver biopsies. Results Serum bilirubin， ALT，GGT and IgG levels in 16 patients with AIH/PBC OS were（45.3±48.3）μmol/L，（ 236.8±71.8）U/L，（ 305.3±258.5）U/L and（25.3±9.9）g/l， significantly different as compared to【（53.4±57.8）μmol/L，（ 77.5±71.7）U/L，（ 389.2±324.3）U/L and （13.9±6.0）g/l， respectively， P<0.05】in 24 patients with PBC; the prevalence of serum ANA， AMA and AMA-M2， but SMA（43.8% in patients with AIH/PBC OS vs. 4.2% in patient with PBC）between the two groups were not significantly different （P>0.05）；we modified five patients' diagnosis from PBC to AIH/PBC OS as the liver histopathological evidence proved， while serum ALT levels in them were 40.0U/L， 82.8U/L， 94.1 U/L， 162.1 U/L and 117.2 U/L， much lower than5 ×ULN. Conclusion For the diagnosis of Chinese patients with AIH/PBC OS，we strongly recommend liver biopsy in order not to miss diagnosis.关键词
原发性胆汁性胆管炎/自身免疫性-原发性胆汁性胆管炎重叠综合征/巴黎标准/诊断Key words
Autoimmune hepatitis/Primary biliary cholangitis overlap syndrome； Primary biliary cholangitis； Paris' criteria； Diagnosis引用本文复制引用
张骏飞,许何明,宋海燕,董静,潘劲劲,陈照林,徐军,陈从新,刘波..自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征:巴黎标准诊断中国患者灵敏度低[J].实用肝脏病杂志,2019,22(4):537-540,4.
