This project was approved by the institutional review board central committee at Fuwai Hospital,National Center for Cardiovascular Diseases,China.Written informed consent was obtained from eligible patients before registration.The data used in our study was from CAMI registry dataset and is not publicly available but is available from corresponding author on reasonable request.The authors declare that they have no competing interests.This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-1-009),the Twelfth Five-Year Planning Project of the Scientific and Technological Department of China (2011BAI11B02),and 2014 Special fund for scientific research in the public interest by National Health and Family Planning Commission of the People's Republic of China (No.201402001).We are very grateful to the TIMI Study Group and the Duke Clinical Research Institute for their contributions in the design,conduct,and data analyses of CAMI registry.We also want to thank all the investigators and coordinators for their great work and active participation.We thank Sara Connell,OD,from Liwen Bianji,Edanz Editing China (www.liwenbianji.cn/ac),for editing the English text of a draft of this manuscript. （CIFMS）