动物营养学报2019，Vol.31Issue(6)：2458-2464,7.DOI:10.3969/j.issn.1006⁃267x.2019.06.002
维生素 A对动物氧化应激的减缓作用机制
Mitigation Mechanism of Vitamin A on Oxidative Stress in Animals
摘要
Abstract
Excessive production of arachidonic acid ( ARA) , reactive oxygen species and nitric oxide ( NO) can cause oxidative damage in cells. Vitamin A can effectively regulate ARA and NO production and play an important role in alleviating oxidative stress. In this paper, the mitigation mechanism of vitamin A on oxidative stress of animals was reviewed from the point of views of increasing the expression and activities of selenopro?tein glutathione peroxidase ( GPx) and thioredoxin reductase ( TrxR) , and regulating the excessive production of ARA and NO via TrxR/mitogen activated protein kinase ( MAPK) pathway and nuclear factor E2 related factor 2 ( Nrf2)/GPx1/nuclear transcription factor?κB ( NF?κB) pathway. It would provide a theoretical basis for the study of the regulation mechanism of vitamin A on oxidative stress.[ Chinese Journal of Animal Nutri?tion, 2019, 31(6) :2458?2464]关键词
维生素A/动物/氧化应激/调节机制Key words
vitamin A/animals/oxidative stress/regulation mechanism分类
农业科技引用本文复制引用
石惠宇,闫素梅..维生素 A对动物氧化应激的减缓作用机制[J].动物营养学报,2019,31(6):2458-2464,7.基金项目
国家自然科学基金项目(31160466) （31160466）
