康复学报2018，Vol.28Issue(2)：37-42,6.DOI:10.3724/SP.J.1329.2018.02037
伊立替康致小鼠消化与免疫系统不良反应研究
Experimental Study of Irinotecan Induced Side Effects on Digestive and Immune System of Mice
摘要
Abstract
Objective:To investigate irinotecan(CPT-11)-induced side effects on the digestive and immune system of mice.Methods:24 male BABL/c mice were randomly divided into model group(n=12)and control group(n=12). The mice in the model group were given CPT-11 by intraperitoneal injection, the control group were given same volumes PBS by intraperitoneal injection.Body weight, diarrhea index, spleen index, thymus index, complete blood count and pathological changes of the jejunum, ileum and colon were measured on the second day and the fourth day after CPT-11 intervention. Results:Compared with the control group, mice body weight was decreased significantly on the second day and the fourth day upon CPT-11 intervention while diarrhea index was increased(P＜0.05); CPT-11 intervention also decreased spleen index, thymus index(P＜0.05), white blood cell count and neutrophil count profoundly along with significant jejunum, ileum and colon injury of the mice. Conclusion:CPT-11 can induce side effects about the digestive and immune system, which consistents with the clinical side effects of CPT-11, and this will be helpful for the further development of novel supplementary therapies for CPT-11 induced toxicity.关键词
伊立替康/消化系统/免疫系统/不良反应/小鼠Key words
irinotecan/digestive system/immune system/side effects/mice引用本文复制引用
刘丽雅,Thomas Joseph SFERRA,Senthilkumar SANKARARAMAN,陈友琴..伊立替康致小鼠消化与免疫系统不良反应研究[J].康复学报,2018,28(2):37-42,6.基金项目
国家自然科学基金项目(81673721) （81673721）
