分子影像学杂志2019，Vol.42Issue(2)：267-270,4.
卵巢畸胎瘤相关性抗N-甲基-D-天冬氨酸受体脑炎: 7例报告并文献复习
Clinical analysis of 7 cases of ovarian teratoma complicated with anti-N-methyl-D-aspartate receptor encephalitis
王观凤 1张赛男 1郑丽娇 1彭冬先1
作者信息
- 1. 南方医科大学珠江医院妇产科，广东 广州 510220
- 折叠
摘要
Abstract
ObjectiveTo evaluate the clinical characteristics, treatment and prognosis of ovarian teratoma patients complicated with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.MethodsThe clinical data of 7 patients with ovarian teratoma complicated with anti-NMDAR encephalitis treated in Zhujiang Hospital of Southern Medical University from July, 2014 to December, 2017 were collected and analyzed retrospectively .ResultsThe average age of the 7 patients was 26 years old. All the patients had abnormal mental behavior, and 2 patients had psychosis as the first symptom. 3 patients were ventilated by tracheotomy because of central hypoventilation, while 1 patient showed only abnormal mental behavior and prodromal symptoms. Anti-NMDAR antibodies were detected in cerebrospinal fluid test in all 7 patients, but Blood samples were tested only in 6 patients. All the patients Included had ovarian teratoma, and all of them improved after the resection of ovarian teratoma. No recurrence was observed during subsequent follow-up.ConclusionsAnti-NMDAR encephalitis is a new type of marginal leaf paraneoplastic encephalitis, which is closely related to ovarian teratoma. The prognosis of the patients with anti NMDAR encephalitis with ovarian teratoma is better, and most of the patients can be recovered after surgical excision of ovarian teratoma.关键词
畸胎瘤/ 抗N-甲基-D-天冬氨酸受体/ 脑炎/ Key words
teratoma/ N-methyl-D-aspartate receptor/ encephalitis/ 引用本文复制引用
王观凤,张赛男,郑丽娇,彭冬先..卵巢畸胎瘤相关性抗N-甲基-D-天冬氨酸受体脑炎: 7例报告并文献复习[J].分子影像学杂志,2019,42(2):267-270,4.
