国际医药卫生导报2019，Vol.25Issue(5)：692-695,4.DOI:10.3760/cma.j.issn.1007-1245.2019.05.006
丹红注射液对糖尿病肾病患者肾功能的保护作用研究
Protective effect of Danhong Injection on renal function in patients with diabetic nephropathy
摘要
Abstract
Objective To investigate the protective mechanism of Danhong Injection on renal function in patients with diabetic nephropathy (DN).Methods 160 cases of DN admitted to our hospital from September,2014 to September,2017 were selected.According to the random number table method,they were divided into a control group and an an observation group,80 cases for each group.The control group were conventionally controlled blood pressure,glucose,and lipid;in addition,the observation group took Danhong Injection.Both groups were treated for 4 weeks.The effects of the two groups were compared;and the serum levels of interleukin -2 (IL-2),soluble interleukin-2 receptor (sIL-2R),tumor necrosis factor-alpha (TNF-α),serum creatinine (Cr),urea nitrogen (BUN),and nitric oxide (NO) were measured before and after the treatment.The changes in hemorheology was analyzed.The urine protein quantitation (24hUTP) level was measured by urine sampling.Results The total effective rate was 93.75％ in the observation group,and was 82.50％ in the control group,with a statistical difference (P ＜ 0.05).The serum levels of IL-2,sIL-2R,and TNF-alpha as well as the viscosity of high / low cut whole blood,hematocrit,fibrinogen,plasma viscosity,Cr,BUN,and 24hUTP were lower and the plasma NO level was higher in the observation group than in the control group,with statistical differences (all P ＜ 0.05).The incidence of adverse reactions was 3.75％ in the observation group,and was 2.50％ in the control group (P ＞ 0.05).Conclusion Danhong Injection may protect the kidneys alleviating the inflammatory reaction of DN patients and improving the kidneys' high blood viscosity and hypercoagulability.关键词
糖尿病肾病/丹红注射液/肾功能/血液流变学Key words
Diabetic nephropathy/Danhong injection/Renal function/Hemorheology引用本文复制引用
陈西慧,张玉琴..丹红注射液对糖尿病肾病患者肾功能的保护作用研究[J].国际医药卫生导报,2019,25(5):692-695,4.基金项目
张玉琴全国名老中医传承工作室建设项目(2016)Constructive Project of Office of Traditional Chinese Medicine Inheritance of National Professional Zhang Yuqin (2016) （2016）
