国际医药卫生导报2019，Vol.25Issue(5)：767-769,3.DOI:10.3760/cma.j.issn.1007-1245.2019.05.029
YKL-40在小儿支气管哮喘外周血中的表达及其与肺功能的相关性
Expression of YKL-40 in peripheral blood of children with bronchial asthma and its correlation with pulmonary function
摘要
Abstract
Objective To investigate the expression of chitin protein 40 (YKL-40) in the peripheral blood of children with bronchial asthma and its correlation with pulmonary function.Methods The clinical data of 80 children with bronchial asthma admitted into our hospital from April,2017 to June,2018 were retrospectively analyzed.According to the ATC score,all the children were divided into group A (40 cases) and group B (40 cases).Another 40 healthy children were selected as a control group.The serum YKL-40,FEV1％,and FEV1/FVC in the three groups were measured.The correlation of YKL-40 with FEV1％ and FEV1/FVC was analyzed.Results The serum YKL-40 level was higher and the FEV1％ and FEV1/FVC were lower in group A and group B than in the control group [(165.32±13.77) ng/ml vs.(122.61±14.94) ng/ml vs.(109.33±6.29) ng/ml,(50.08±3.09)％ vs.(79.97±3.55)％ vs.(92.57±4.97)％,and (56.35±3.36) vs.(65.48±14.26) vs.(75.50±4.53);all P ＜ 0.05)].Pearson correlation analysis showed that the serum YKL-40 level negatively correlated with FEV1％ and FEV1/FVC (r ＜ 0,P ＜ 0.05).Conclusions The level of YKL-40 in the peripheral blood of children with bronchial asthma increases obviously,and decreases with the increase of pulmonary function index,so it can be used as an important serological index to judge the degree of asthma development.关键词
小儿支气管哮喘/甲壳质酶蛋白40/肺功能Key words
Bronchial asthma in children/Chitin protein 40/Pulmonary function引用本文复制引用
刘保华..YKL-40在小儿支气管哮喘外周血中的表达及其与肺功能的相关性[J].国际医药卫生导报,2019,25(5):767-769,3.
