国际医药卫生导报2019，Vol.25Issue(13)：2046-2049,2081,5.DOI:10.3760/cma.j.issn.1007-1245.2019.13.010
血清HBV pgRNA在慢性乙型肝炎患者聚乙二醇化干扰素抗病毒过程中的临床价值
Clinical significance of HBV pgRNA in antiviral treatment with interferon for patients with chronic hepatitis B
摘要
Abstract
Objective Through the dynamic observation of HBV pgRNA,HBV DNA,serological and biochemical indicators in the antiviral process of patients with chronic hepatitis B,to explore the clinical significance of HBV pgRNA in the anti-viral process of chronic hepatitis B,and to further explore the HBV pgRNA at the end of antiviral therapy.Methods Eighteen patients with chronic hepatitis B were treated with pegylated interferon antiviral therapy (Peg-IFN) for 48 weeks.The HBV pgRNA levels,HBV DNA levels,and serological and biochemical indicators were tested at 0,12,24,36 and 48 weeks of the treatment.The correlation among the above indicators was statistically analyzed.Results During the Peg-IFN treatment,the HBV DNA and HBV pgRNA levels decreased.The HBV pgRNA levels correlated with HBeAg (P ＜ 0.001),but not with HBsAg (P ＞ 0.05).HBV DNA was positively correlated with HBV pgRNA in the HBV DNA-positive patients (P ＜ 0.01).The treatment time was affected by HBV pgRNA.There were no significant correlations between the levels of independent influencing factors and other indicators (P ＞ 0.05).In 4,22％ of the patients,the HBsAg began to decrease at the 24th week of the treatment and when HBV pgRNA was close to the minimum detection limit,and had been declining for the last 24 weeks.At the 24th week of treatment,if HBV pgRNA ≥ 103 copies/ml,there was no significant decrease in HBsAg;and if HBV pgRNA was below the minimum detection limit at week 24 of treatment,the HBV pgRNA levels would continue to be below the test value during the last 24 weeks of treatment.Conclusion HBV pgRNA may better reflect the inhibition of viral replication by interferon,and has a predictive effect on immunological response,which is helpful for the judgment of therapeutic efficacy and has certain clinical value for guiding individualized treatment.However,the sample size of this study is small,and large samples are still needed for further verification.关键词
HBV pgRNA/慢性乙型肝炎/聚乙二醇化干扰素Key words
HBV pgRNA/Chronic hepatitis B/Polyglycol interferon引用本文复制引用
朱莹,杨可立,李锋,关玉娟,陆霭琪,李剑萍..血清HBV pgRNA在慢性乙型肝炎患者聚乙二醇化干扰素抗病毒过程中的临床价值[J].国际医药卫生导报,2019,25(13):2046-2049,2081,5.基金项目
Project Supported by Research Fund of Medical Science and Technology in Guangdong (A2019296) （A2019296）
Research Fund of Medical Science in Guangdong (YWJKJJHKYJJ-B17343) （YWJKJJHKYJJ-B17343）
Project for Key Medical Subject Construction in Guangzhou (2017-2019)广东省医学科学技术研究基金项目(A2019296) （2017-2019）
广东省医学科学研究基金(YWJKJJHKYJJ-B17343) （YWJKJJHKYJJ-B17343）
广州市医学重点学科建设项目(2017-2019年) （2017-2019年）
