国际医药卫生导报2019，Vol.25Issue(14)：2272-2276,5.DOI:10.3760/cma.j.issn.1007-1245.2019.12.020
超保守基因序列uc.189在子宫内膜样腺癌中的表达及其临床意义研究
Expression of ultra-conserved regions uc.189 in endometrioid adenocarcinoma and its clinical significance
摘要
Abstract
Objective To study the expression of ultra-conserved regions uc.189 in endometrioid adenocarcinoma and its correlation with clinical parameters.Methods 65 patients with endometrioid adenocarcinoma treated at our hospital were selected.The expression levels of uc.189 in adjacent normal tissue and cervical cancer tissue were detected by real-time quantitative PCR and RNA in situ hybridization,and compared.The correlation of the expression level in cancer tissue with clinicopathological parameters and clinical prognosis was analyzed.Results The uc.189 protein was localized in the cytoplasm of the tumor cells,it was highly expressed in the tumor tissue (13.863±2.061),which was significantly higher than that in the adjacent normal tissue [(3.605±0.887),P ＜ 0.05].The uc.189 expression level was not statistically different in the patients' age (P=0.881),tumor maximum diameter (P=0.845),and tumor local infiltration stage (P=0.061);but were in tumor pathological grade (P=0.007),lymph node metastasis (P=0.038),and TNM clinical stage (P＜ 0.001).The clinical prognosis of the vendometrioid adenocarcinoma patients with high expression of uc.189 was significantly worse than that of the endometrial adenocarcinoma patients with low or no expression of uc.189 (P ＜ 0.01).Conclusion The ultra-conserved regions uc.189 is highly expressed in endometrioid adenocarcinoma tumor tissue;and its expression level is closely related to the patients' clinicopathological parameters.The higher expression level of ue.189 in tumor tissue is,the worse the patients' clinical prognosis is.Ultra-conserved regions uc.189 can be used as a prognostic indicator for endometrial adenocarcinoma patients.关键词
超保守基因序列/uc.189/子宫内膜样腺癌/表达/预后/相关性Key words
Ultra-conserved regions/uc.189/Endometrioid adenocarcinoma/Expression/Prognosis/Correlation引用本文复制引用
王磊,丁永玲,蒋淑婉,黄彩虹,周洁,唐嘉阅,丁艳..超保守基因序列uc.189在子宫内膜样腺癌中的表达及其临床意义研究[J].国际医药卫生导报,2019,25(14):2272-2276,5.基金项目
2018年扬州大学附属医院科研基金项目 （）
Project Supported by Scientific Research Fund of Hospital Affiliated to Yangzhou University in 2018 （）
