赣南医学院学报2019，Vol.39Issue(1)：1-6,6.DOI:10.3969/j.issn.1001-5779.2019.01.001
油茶皂苷对小鼠DSS诱导结肠炎影响的研究
The effect of Sasanquasaponin treatment on dextran sodium sulfate-induced colitis
摘要
Abstract
Objeetive:Sasanquasaponin(SQS) is an extract from Camellia oleifera Abel,which is considered to have an anti-inflammatory property.This study is to determine whether SQS can prevent experiment colitis induced by dextran sodium sulfate (DSS).Method:C57BL/6 mice were randomly divided into 5 groups.The experiment groups were treated by intragastric injection with different concentrates of SQS for 21 days,and then treated with DSS for 5 days to induce colitis.We recorded the body weights and colon lengths of mice.colons were also sectioned for hematoxylin & eosin(H&E) staining.The gene expression of pro-inflammatory cytokines,including TNF-a,IL-1 β,MCP-1,and iNOS in colon were determined.Results:Compared to the control group,body weights and colon lengths in the DSS group were decreased significantly.But,we could not observe remission of inflammation based on the parameters such as body weight,colon length and H&E staining,and gene expression of pro-inflammatory cytokines,in SQS-treated groups in comparison with ISS model group.Conclusions:SQS had not shown the effect of preventing DSS-induced colitis in our current study.关键词
油茶皂苷/结肠炎/炎性细胞因子Key words
Sasanquasaponin/colitis/pro-inflammatory cytokines分类
医药卫生引用本文复制引用
文志勇,张琼,周子涵,沈镇平,李洪亮,刘志平..油茶皂苷对小鼠DSS诱导结肠炎影响的研究[J].赣南医学院学报,2019,39(1):1-6,6.基金项目
This work was supported by funds from Talents' Start-up Fund of Gannan Medical University (QD201404) （QD201404）
National Natural Science Foundation of China (31560260) （31560260）
Camellia Special Project of Gannan Medical University (YC201501) （YC201501）
and Collaborative Innovation Center for Gannan Oil-tea Camellia Industrial Development (YK201603) （YK201603）
