湖南中医药大学学报2018，Vol.38Issue(9)：981-985,5.DOI:10.3969/j.issn.1674-070X.2018.09.003
心气阴两虚证心力衰竭大鼠血浆代谢组学研究
Plasma Metabonomics of Rats with Heart Failure with Heart-Qi Yin Deficiency Syndrome
摘要
Abstract
Objective To investigate the features of plasma metabonomics in rats with heart failure with heart -Qi Yin deficiency syndrome. Methods Dahl salt -sensitive rats were divided into model group and normal group. The rats in the model group were given high-salt fodder to establish a model of heart failure. After modeling, plasma samples were collected from 7 rats in the model group and 8 in the normal group, and gas chromatography-mass spectroscopy and a multivariate statistical analysis were performed for analysis. Results The score chart obtained by principal component analysis and partial least squares -discriminant analysis showed that the integral point of metabolic components was completely separated between the two groups, indicating that there was a significant difference in metabolic pattern between the two groups. The orthogonal partial least squares-discriminant analysis of the variables with between-group differences showed that compared with the normal group, the model group had significant increases in the concentrations of threonic acid, cysteine, ornithine, alanine, 4-hydroxy-proline, threonine, methyl cysteine, asparagine, arachidonic acid, cholesterol, D-threitol, pyruvic acid, and pyroglutamic acid and significant reductions in the concentrations of tryptophan, leucine, xylitol, ribitol, malonic acid, and carbamide. Conclusion There are changes in the plasma metabonomics of rats with heart failure, and differential metabolites are associated with disorders of amino acid metabolism, lipid metabolism, and glucose metabolism and abnormal liver function.关键词
心力衰竭/心气阴两虚证/代谢组学Key words
heart failure/heart-Qi Yin deficiency syndrome/metabonomics分类
医药卫生引用本文复制引用
钟森杰,李欣春,李杰,胡志希,简维雄,周瑶,姚涛,杨梦..心气阴两虚证心力衰竭大鼠血浆代谢组学研究[J].湖南中医药大学学报,2018,38(9):981-985,5.基金项目
国家自然科学基金项目(81774208,81774207,81373550). （81774208,81774207,81373550）
