湖南中医药大学学报2018，Vol.38Issue(9)：986-989,4.DOI:10.3969/j.issn.1674-070X.2018.09.004
大鼠失眠模型造模中对氯苯丙氨酸混悬液改良法的探讨
An Improved Method for the Preparation of Para-chlorobenzalanine Suspension in a Rat Model of Insomnia
摘要
Abstract
Objective To explore the improved method of preparing para -chlorophenylalanine (PCPA) suspension in a rat model of insomnia, and evaluate the effect of modeling. Methods In the 98 SD rats, 50 rats were treated with NaOH solution preparing method, 24 SD rats were modeled with NaHCO3 solution preparing method, and 24 SD rats were treated with the improved method to establish the model of insomnia rats. Results There were 50 failed model rats with NaOH solution preparing method, 24 failed model rats with NaHCO3 solution preparing method. The 24 model rats succeed by the improved method, and the 0.5 g/kg of PCPA was the best dose to establish the model (P ＜0.05). Conclusion The improved preparing method of PCPA suspension can successfully make the rat model of insomnia.关键词
对氯苯丙氨酸/失眠/造模Key words
para-chloropbenylalanine/insomnia/model分类
医药卫生引用本文复制引用
魏歆然,郑雪娜,裴芸,吴雪芬,刘丽,陈小丽,文琪琦,岳增辉,魏高文..大鼠失眠模型造模中对氯苯丙氨酸混悬液改良法的探讨[J].湖南中医药大学学报,2018,38(9):986-989,4.基金项目
国家重点基础研究发展计划(973计划)(2014CB543102). （973计划）
