湖南中医药大学学报2018，Vol.38Issue(9)：994-998,5.DOI:10.3969/j.issn.1674-070X.2018.09.006
清霾饮防治PM2.5致大鼠肺损伤的研究
Qingmai Decoction in the Prevention and Treatment of Fine Particulate Matter-Induced Pulmonary Impairment in Rats
摘要
Abstract
Objective To investigate the significance of Qingmai Decoction in the prevention and treatment of fine particulate matter (PM2.5) -induced pulmonary impairment in rats. Methods Fifty healthy adult Sprague -Dawley rats were randomly divided into blank group, PM2.5 exposure group, low-dose Qingmai Decoction group, medium-dose Qingmai Decoction group, and high-dose Qingmai Decoction group. Fine particles in the air were collected and made into a liquid suspension with a concentration of 37.5 mg/ml, which was used to treat rats to establish a model of pulmonary impairment. Rats were given different doses of Qingmai Decoction for intervention. At 48 hours after the last exposure, abdominal aortic blood and bronchoalveolar lavage fluid (BALF) of the right lung were collected to determine the activity of acid phosphatase (ACP) and lactic dehydrogenase (LDH) in serum and BALF as well as the activity of glutathione peroxidase (GSH-Px) in serum. Pathological section of the right lung lobe was evaluated. Results Compared with the blank group, the PM2.5 exposure group had significantly higher activity of ACP and LDH in BALF and serum and significantly lower activity of GSH-Px in serum (P＜0.01). There were no significant differences in any indices between the PM2.5 exposure group and low-dose Qingmai Decoction group (P＞ 0.05). Compared with the PM2.5 exposure group, the medium- and high-dose Qingmai Decoction groups had significantly lower activity of ACP and LDH in BALF and serum and significantly higher activity of GSH-Px in serum (P＜0.05). Conclusion Qingmai Decoction can protect the lung tissue by antagonizing the PM2.5-induced inflammatory and oxidative damages.关键词
细颗粒物(PM2.5)/清霾饮/支气管肺泡灌洗液/肺损伤Key words
fine particulate matter(PM2.5)/Qingmai Decoction/bronchoalveolar lavage fluid/pulmonary impairment分类
医药卫生引用本文复制引用
赵群菊,田珺,郭时印,蒋俊和..清霾饮防治PM2.5致大鼠肺损伤的研究[J].湖南中医药大学学报,2018,38(9):994-998,5.基金项目
湖南省中医药科研计划项目(60010783). （60010783）
