湖南中医药大学学报2018，Vol.38Issue(11)：1258-1261,4.DOI:10.3969/j.issn.1674-070X.2018.11.008
隔药饼灸对高脂血症合并动脉粥样硬化兔血清TNF-α、INF-γ含量的影响
Effect of Herbal Cake-Separated Moxibustion on the Expression of Serum TNF-α and INF-γ in Rabbits with Hyperlipidemia and Atherosclerosis
摘要
Abstract
Objective To observe the effect of herbal cake-separated moxibustion on the expression of tumor necrosis factor alpha (TNF-α) and interferon gamma (INF-γ) in the serum of rabbits with hyperlipidemia and atherosclerosis, and to investigate the mechanism of its anti-atherosclerotic effect. Methods A total of 40 New Zealand white rabbits were randomly divided into five groups, namely blank control group (normal group), model group, herbal cake-separated moxibustion group, direct moxibustion group, and simvastatin group, with eight rabbits in each group. A hyperlipidemia and atherosclerosis rabbit model was established by feeding high-fat diet to the animals. After successful modeling, all the five groups, except the blank control group, received corresponding treatment once a day for four successive weeks; then enzyme-linked immunosorbent assay was used to determine the levels of TNF-α and IFN-γ in the serum of the rabbits. Results Theexpression levels of TNF-α and IFN-γ in the serum increased significantly in the model group, the direct moxibustion group, and the simvastatin group compared with those in the normal group (P＜0.01 or P＜0.05); the serum levels of TNF-α and IFN-γ decreased significantly in the direct moxibustion group, the simvastatin group, and the herbal cake-separated moxibustion group compared with that in the model group (P＜0.01 or P＜0.05); compared with the normal group, the herbal cake-separated moxibustion group had a significantly increased expression level of serum TNF-α (P ＜0.05), but there was no significant difference between the two groups in the serum level of IFN-γ despite an increasing trend in the herbal cake-separated moxibustion group (P＞0.05). Conclusion The effect on relevant inflammatory factors (TNF-α and IFN-γ) in the serum of atherosclerotic rabbits is one of the anti-atherosclerotic mechanisms of herbal cake-separated moxibustion.关键词
隔药饼灸/高脂血症/动脉粥样硬化/肿瘤坏死因子α/干扰素γKey words
herbal cake-separated moxibustion/hyperlipidemia/atherosclerosis/tumor necrosis factor alpha/interferon gamma分类
医药卫生引用本文复制引用
阳晶晶,赵钊,石佳,葛君芸,欧阳里知,常小荣,刘迈兰,黄洁..隔药饼灸对高脂血症合并动脉粥样硬化兔血清TNF-α、INF-γ含量的影响[J].湖南中医药大学学报,2018,38(11):1258-1261,4.基金项目
国家自然科学基金项目(81273828 （）
81273830 （）
81704182) （）
湖南省自然科学基金项目(2018JJ3397) （2018JJ3397）
