湖南中医药大学学报2018，Vol.38Issue(11)：1283-1287,5.DOI:10.3969/j.issn.1674-070X.2018.11.013
雌激素受体α基因XbaⅠ、PvuⅡ位点多态性与女性膝骨关节炎易感性关系的Meta分析
Association Between Estrogen Receptor Alpha Gene XbaⅠ and PvuⅡ Polymorphisms and Susceptibility to Knee Osteoarthritis in Women: A Meta-analysis
摘要
Abstract
Objective To investigate the association between estrogen receptor alpha (ER-α) gene XbaⅠ and PvuⅡ polymorphisms and susceptibility to knee osteoarthritis (KOA) in women. Methods A literature search was performed in PubMed, EMBASE, CENTRAL, Web of Science, Ovid, CNKI, VIP, and Wangfang Data to collect the studies on the association between ER-α gene XbaⅠ (A/G) and PvuⅡ (T/C) polymorphisms and susceptibility to KOA in women. The relevant data were extracted, and then odds ratio and 95％ confidence interval were calculated. A meta-analysis was performed using STATA 11 software. Results A total of 9 case-control or cohort studies in seven publications involving 2194 KOA cases and 2959 controls were included in the metaanalysis. By pooling all the studies, either XbaⅠ or PvuⅡ polymorphism was not significantly associated with KOA risk in women (P＞0.05). In the subgroup analysis by ethnicity, XbaⅠ polymorphism (G vs A; GG vs AA; GG+AG vs AA; GG vs AG+AA) was significantly associated with decreased KOA risk in Asian women (P＜0.01); PvuⅡ polymorphism (C vs T; CC vs TT; CC vs CT+TT) was significantly associated with increased KOA risk in Asian women (P ＜0.01). Conclusion ER-α gene PvuⅡ and XbaⅠ polymorphisms are found to be associated with susceptibility to KOA in Asian women only. However, the sample size of this analysis is small, and more studies are needed to confirm this conclusion.关键词
膝骨关节炎/雌激素受体α/基因多态性/Meta分析Key words
knee osteoarthritis/estrogen receptor alpha/gene polymorphism/Meta-analysis分类
医药卫生引用本文复制引用
周予婧,邹莹洁,谭洁,艾坤,张泓..雌激素受体α基因XbaⅠ、PvuⅡ位点多态性与女性膝骨关节炎易感性关系的Meta分析[J].湖南中医药大学学报,2018,38(11):1283-1287,5.基金项目
国家自然科学基金资助项目面上项目(81473753) （81473753）
湖南中医药大学校级青年教师科研基金课题 （）
