湖南中医药大学学报2018，Vol.38Issue(11)：1326-1330,5.DOI:10.3969/j.issn.1674-070X.2018.11.024
百合地黄汤对抑郁症大鼠血清IL-10和海马DA的影响
Effect of Baihe Dihuang Decoction on Serum Anti-inflammatory Factor Inerleukin-10 and Hippocampal Neurotransmitter Dopamine in Rats with Depression
摘要
Abstract
Objective To investigate the effect of Baihe Dihuang Decoction on serum anti-inflammatory factor interleukin-10 (IL-10) and hippocampal neurotransmitter dopamine (DA) in rats with depression induced by chronic stress, and to provide a basis for the role of Baihe Dihuang Decoction in the treatment of depression. Methods A total of 50 adult female Sprague-Dawley rats were randomly divided into blank control group, model group, low-and high-dose Baihe Dihuang Decoction groups, and fluoxetine group, with 10 rats in each group. A rat model of depression was established by chronic stress stimulation and isolated feeding. After the model was established, the rats in the model group and the blank control group were given normal feeding, and those in the other groups were given corresponding intervention. On day 28 after modeling, the open field test and forced swimming test were used for behavioral assessment, ELISA was used to measure the serum level of IL-10, and immunohistochemistry was used to measure the expression of DA in the hippocampus. Results Compared with the blank control group, the model group had a significant reduction in the total score of open field test, a significant increase in immobility time in forced swimming test, andsignificant reductions in serum IL-10 and hippocampal DA (P＜0.01). Compared with the model group, the low-and high-dose Baihe Dihuang Decoction groups had a significant increase in the total score of open field test, a significant reduction in immobility time in forced swimming test, and significant increases in serum IL-10 and hippocampal DA (P ＜0.01). Conclusion Baihe Dihuang Decoction exerts a therapeutic effect on depressive state in rats with depression, possibly by effectively regulating serum IL-10 and hippocampal DA.关键词
百合地黄汤/白介素-10/多巴胺/抑郁症Key words
Baihe Dihuang Decoction/interleukin-10/dopamine/depression分类
医药卫生引用本文复制引用
王海兰,周湘乐,谭婷,肖碧跃..百合地黄汤对抑郁症大鼠血清IL-10和海马DA的影响[J].湖南中医药大学学报,2018,38(11):1326-1330,5.基金项目
湖南省科技厅项目(2015JC3077) （2015JC3077）
