昆明医科大学学报2018，Vol.39Issue(3)：119-124,6.
Gas6与2型糖尿病及其并发症的研究进展
Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications
摘要
Abstract
Growth arrest-specific 6, which is a member of the vitamin K-dependent protein family, is a ligand of TAM (Tyro3, Axl, Mer) belonging to the receptor tyrosine kinase family.Gas6/Axl signaling pathways are involved in pathophysiological processes of cell adhesion, migration, proliferation, apoptosis, platelet aggregation, vascular remodeling, inflammatory and immune responses. In recent years, studies found that Gas6/Axl signaling pathway, Gas6 level and the gene polymorphism of Gas6 were significantly associated with type 2 diabetes, obesity, insulin resistance and diabetic complications.This article reviews the correlation between Gas6 and type 2 diabetes and its complications关键词
Gas6/2型糖尿病/肥胖/胰岛素抵抗/并发症Key words
Growth arrest-specific 6/Type 2 diabetes mellitus/Obesity/Insulin resistance/Diabetic complications分类
医药卫生引用本文复制引用
董雪娥,李会芳..Gas6与2型糖尿病及其并发症的研究进展[J].昆明医科大学学报,2018,39(3):119-124,6.基金项目
国家自然科学基金资助项目(81160104,30760087) （81160104,30760087）
云南省卫生科技计划项目(2017NS049) （2017NS049）
