昆明医科大学学报2018，Vol.39Issue(8)：93-98,6.
血流动力学监测指导下肾移植术中去甲肾上腺素的应用
An Application of Norepinephrine in Renal Transplantation Guided by Hemodynamic Monitoring
摘要
Abstract
Objective To investigate the use of noradrenaline under different monitoring methods in renal transplantation and its clinical significance in prognosis. Methods 40 patients under the surgery of renal allograft were randomly divided into two groups (20 patients each): Flotrac-vigileo group (E) and the standard monitoring group (N), then we recorded MAP (mean arterial pressure), CVP (central venous pressure) and HR (heart rate) value divided by 5 periods: after induction of general anesthesia (T1), before operation (T2), external iliac vein occlusion (T3), external iliac vein opening (T4) and the end of operation (T5).Meanwhile, intraoperative norepinephrine dosage, intake and output volumnand renal function indicators during postoperative and after three days were also studies. Length of hospital stay were also compared in this essay.Results The amount of norepinephrine in group E during operation was significantly lower than that in group N (P＜0.05). The urine volume in group E during operation was significantly higher than that in group N (P＜0.05). There was no significant difference between the two groups in the amount of transfusion, blood loss and the indexes of kidney function. Conclusions Hemodynamics monitored by peripheral cardiac output significantly reduced the amount of norepinephrine used in renal transplantation, also in the risk of renal damage. Yet it increased the amount of intraoperative urine output, which provided more accurate and personalized management of intraoperative vasoactive drugs.关键词
去甲肾上腺素/肾移植/外周血管阻力/每搏变异度Key words
Norepinephrine/Kidney transplantation/Peripheral vascular resistance/Stroke variation分类
医药卫生引用本文复制引用
张凯璐,李兵,张宇,祝丽芬..血流动力学监测指导下肾移植术中去甲肾上腺素的应用[J].昆明医科大学学报,2018,39(8):93-98,6.基金项目
昆明市科技计划基金资助项目(2015-2-S-01999) （2015-2-S-01999）
