兰州大学学报（医学版）2018，Vol.44Issue(4)：23-26,4.DOI:10.13885/j.issn.1000-2812.2018.04.004
SESN2基因多态性与西北地区人群先天性心脏病易感性分析
Association of SESN2 gene polymorphisms with congenital heart defect susceptibility in the Northwest population
摘要
Abstract
Objective The present study was the fist of its kind to investigate into the relationship between SESN2 gene polymorphism and congenital heart defect (CHD) susceptibility in the Northwest population.Methods A case-control association study in individuals with congenital cardiac septal defects (CCSDs) (n=543) and healthy controls (n=537) was conducted. Two SNPs (rs580800, rs543240) in SESN2 were genotyped by combining PCR-RFLP with Sanger sequencing. Associations were analyzed by chi-square test in SPSS17.0. Results The genotype or allele distribution of two SNPs conform with Hardy-Weinberg equilibrium in case group and control group. The frequencies of genotype or allele of the two tagSNPs in SESN2 gene were not significantly different between CCSDs patients and the healthy controls (P＞0.05) . There were also no significant difference in disease subtype. Conclusions There might not be a significant correlation between SESN2 gene (rs580800, rs543240) and CCSDs.关键词
先天性心脏病/隔膜类缺损/SESN2基因/单核苷酸多态性Key words
congenital heart defect/congenital cardiac septal defects/SESN2/single nucleotide polymorphism分类
医药卫生引用本文复制引用
刘红芳,张学红,王静,谢小冬..SESN2基因多态性与西北地区人群先天性心脏病易感性分析[J].兰州大学学报（医学版）,2018,44(4):23-26,4.基金项目
国家自然科学基金项目(31670379) （31670379）
