兰州大学学报（医学版）2018，Vol.44Issue(4)：40-45,6.DOI:10.13885/j.issn.1000-2812.2018.04.007
hMLH1、hMSH2、hMSH6在中青年散发性胃癌中的表达及对其预后的影响
Expression of hMLH1, hMSH2 and hMSH6 in young and middle-aged patients with sporadic gastric cancer and its effect on prognosis
摘要
Abstract
Objective To discuss expression of hMLH1, hMSH2 and hMSH6 protein in the young and middleaged patients with sporadic gastric cancer (SGC) and their effects on prognosis. Methods To collect 147 cases of SGC paraffin specimens from January 2010 to January 2013 and to analyze the relationship between the expression of mismatch repair protein (MMR) and its clinic pathological features and prognosis. Immunohis-tochemistry was used to detect the expression of h MLH1, hMSH2 and h MSH6 in young SGC. Results The deletion rate of hMLH1 was 20.4％ (30/147), that of hMSH2 7.5％ (11/147) and that of hMSH6 6.1％ (9/147) .The total deletion rate of MMR was 28.6％ (42/147) . The deletion of MMR was significantly different in pTNM stage, tumor differentiation degree and lymph node metastasis (P ＜ 0.05) . The five-year overall survival rate was 64.3％ (27/42) in the deficient mismatch repair protein (dMMR) group and 80.9％ (85/105) in the normal MMR group, and the difference was statistically significant (χ2=4.950, P ＜ 0.05. The multivariate analysis showed that MMR status and lymph node metastasis were independent factors influencing the overall survival time in patients with SGC. Conclusions MMR deletion in young and middle-aged patients with SGC is more common in patients with stage Ⅲ and low differentiation. The deletion MMR group was more likely to undergo lymph node metastasis. The prognosis of the dMMR group was worse than that of the normal MMR group. h MLH1, hMSH2 and hMSH6 may play an important role in the occurrence and development of gastric cancer. Joint detection has a certain value in the diagnosis and treatment of gastric cancer.关键词
错配修复蛋白/胃癌/病理特征/预后Key words
mismatch repair protein/gastric cancer/pathological characteristics/prognosis分类
医药卫生引用本文复制引用
陈鹏,汪文杰,李盖天,李洪涛,韩晓鹏,刘宏斌..hMLH1、hMSH2、hMSH6在中青年散发性胃癌中的表达及对其预后的影响[J].兰州大学学报（医学版）,2018,44(4):40-45,6.基金项目
科技部、财政部惠民计划项目(2012GS620101) （2012GS620101）
甘肃省自然科学基金重点专项(2011GS04390) （2011GS04390）
中国博士后科研流动基金项目(2015M572710) （2015M572710）
