兰州大学学报（医学版）2018，Vol.44Issue(4)：46-52,7.DOI:10.13885/j.issn.1000-2812.2018.04.008
质子放疗联合同步化疗治疗食管癌安全性和疗效的系统评价和Meta分析
Efficacy and safety of proton radiotherapy combined concurrent chemotherapy for esophageal cancer:a systematic review and Meta-analysis
摘要
Abstract
Objective To systematically review the efficacy and safety of the proton radiotherapy combined concurrent chemotherapy for esophageal cancer. Methods Databases including PubMed, Web of Science, Cochrane Library, China Biology Medicine disc were searched to collect clinical studies about proton radiotherapy combined concurrent chemotherapy for esophageal cancer from their inceptions to June 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies.Meta-analysis was then performed using Meta Analyst Beta 3.13 and STATA 12.0 software. Results A total of five studies were included, of which 240 cases were in the proton radiotherapy combined concurrent chemotherapy. The results of Meta-analysis showed that the incidence of grade 2 and over 3 grade of radiation esophagitis was 45.4％ and 14.1％ respectively, the incidence of grade 2 and over 3 grade of radiation pneumonitis was 2.2％ and 1.8％ respectively, the incidence of grade 2 and over 3 grade of radiation-induced heart disease was 6.4％ and 1.6％ respectively, the incidence of grade 2 and over 3 grade of radiodermatitis was22.3％ and 5.6％ respectively, the incidence of grade 2 and over 3 grade of fatigue was 24.2％ and 7.5％respectively, the incidence of grade 2 and over 3 grade of myelosuppression was 46.6％ and 19％ respectively, the incidence of grade 2 and over 3 grade of nausea and vomiting was 32.2％ and 8％ respectively, the 3 years of overall survival, local control rate, relapse free survival and complete remission were 60.4％, 58.8％, 49.6％ and 62.7％ respectively. Conclusions Proton radiotherapy combined concurrent chemotherapy is considered a safe and effective treatment for esophageal cancer. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusions.关键词
质子放疗/同步化疗/食管癌/Meta分析Key words
proton therapy/concurrent chemotherapy/esophageal cancer/Meta-analysis分类
医药卫生引用本文复制引用
葛劲松,王小虎,李祎,田金徽,张秋宁,杨燕,邵丽华,廖亦然..质子放疗联合同步化疗治疗食管癌安全性和疗效的系统评价和Meta分析[J].兰州大学学报（医学版）,2018,44(4):46-52,7.基金项目
国家重点研究发展计划项目(2016YFC0105706) （2016YFC0105706）
国家自然科学基金项目(81160283 （）
81372419) （）
