兰州大学学报（医学版）2018，Vol.44Issue(5)：1-8,8.DOI:10.13885/j.issn.1000-2812.2018.05.001
长链非编码RNA在肺高血压中的研究进展
Advances in studying the role of long noncoding RNA in pulmonary hypertension
摘要
Abstract
Pulmonary hypertension (PH) is a syndrome characterized by persistent increase in pulmonary vascular resistance. Due to lack of specificity in clinical manifestations, patients at the early stage of PH are prone to delayed diagnosis. The prognosis of PH is poor and at the late stage of the disease, it may result in right heart failure and even death. Long noncoding RNA (lncRNA) is a type of non-coding RNA longer than200 nt. LncRNA affects the incidence, progression, and prognosis of diseases through regulating chromatin remodeling and gene expression at the transcriptional and post-transcriptional levels. Among the complicated pathogenic mechanisms of PH, the roles of lncRNA in the pathological remodeling of pulmonary vessels have attracted wide attention. This review sought to elucidate the acting mechanism of lncRNA in PH, in the hope of providing new leads to the diagnosis of and intervention in this disease.关键词
肺高血压/长链非编码RNA/血管重塑Key words
pulmonary hypertension/long noncoding RNA/vascular remodeling分类
医药卫生引用本文复制引用
吴绵绵,郭芳,李亚红,张智,刘珂,曹云山,张琰..长链非编码RNA在肺高血压中的研究进展[J].兰州大学学报（医学版）,2018,44(5):1-8,8.基金项目
国家自然科学基金地区科学基金项目(81460072) （81460072）
2016中国科学院西部之光人才项目 （）
甘肃省自然科学基金项目(17JR5RA057) （17JR5RA057）
天津市自然科学基金重点项目(17JCZDJC35600) （17JCZDJC35600）
国家级和市级大学生创新创业训练计划项目(201810062034) （201810062034）
2017天津市高校"中青年骨干创新人才培养计划"项目 （）
高水平创新人才计划—杰出学者/中青年领军人才项目(YDYYRCXM-B2018-02) （YDYYRCXM-B2018-02）
