兰州大学学报（医学版）2018，Vol.44Issue(5)：76-80,5.DOI:10.13885/j.issn.1000-2812.2018.05.015
经典Wnt信号通路在骨肉瘤中作用的研究进展
Research progress of classical Wnt signaling pathway in osteosarcoma
摘要
Abstract
Osteosarcoma is the most common malignant tumor in bone tissue, whose high degree of malignancy especially preys on children and adolescents. Wnt signaling pathway is a signal pathway containing a highly conserved base sequence that regulates cell polarity, proliferation, differentiation and embryo development, tissue homeostasis and cell carcinogenesis, tumor cell invasion and metastasis and many other biological processes. The study found that classical Wnt/β signaling pathway and the occurrence and development of osteosarcoma were closely related. classical Wnt/β signaling pathway in osteosarcoma cell proliferation, invasion and metastasis and other important regulations could provide an important direction and method research into the pathogenesis of osteosarcoma and metastasis mechanism and chemotherapy resistance.关键词
骨肉瘤/经典Wnt信号通路/β-联蛋白Key words
osteosarcoma/classical Wnt/β sigaling pathway/β-catenin分类
医药卫生引用本文复制引用
赵珂,韩兴文,王文己..经典Wnt信号通路在骨肉瘤中作用的研究进展[J].兰州大学学报（医学版）,2018,44(5):76-80,5.基金项目
甘肃省自然科学基金项目(1606RJZA126) （1606RJZA126）
