兰州大学学报（医学版）2018，Vol.44Issue(6)：50-56,7.DOI:10.13885/j.issn.1000-2812.2018.06.010
术前SII、NLR、PLR在分化型甲状腺癌中的诊断价值分析
Diagnostic value of preoperative systemic immune-inflammation index, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in differentiated thyroid carcinoma
摘要
Abstract
Objective By analyzing the differences of systemic immune-inflammation index(SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) between patients of differentiated thyroid cancer (DTC) and benign thyroid nodules, aimed at evaluating the diagnostic value of SII, NLR and PLR in differential diagnoses of benign and malignant thyroid nodules. Methods A retrospective study was performed to analyze the clinical data of patients with thyroid nodules who accepted surgery treatment for the first time in the Characteristic Medical Center of Chinese People's Armed Police Forces from June 2014 to December 2017. The patients were divided into a benign nodules group and DTC group according to postoperative pathological results. The differences of SII, NLR and PLR between the two groups were discussed. Furthermore, the optimal cut-off value of SII and NLR to discriminate between benign and malignant nodules of thyroid was obtained via the receiver operator characteristic curve (ROC). Results SII and NLR were significantly different between the two groups (P ＜ 0.01). PLR was no significantly different (P ＞ 0.05). The optimal SII cut-off point obtained from ROC analysis was 520.65 (sensitivity 41.6％, specificity 87.0％, positive predict value 70.0％, negative predict value 64.8％), while area under curve (AUC) was 0.659. The optimal NLR cutoff point obtained from ROC analysis was 1.81 (sensitivity 62.4％, specificity 83.9％, positive predict value 74.5％, negative predict value 73.4％), while AUC was 0.720. Conclusion Preoperative higher SII and NLR values have certain diagnostic value for DTC. In clinical work, preoperative SII and NLR values can be used to guide the differential diagnosis of benign and malignant thyroid nodules, provide an important reference for a comprehensive assessment of thyroid nodules.关键词
分化型甲状腺癌/系统性免疫性炎症指数/中性粒细胞和淋巴细胞比值/血小板和淋巴细胞比值/鉴别诊断Key words
differentiated thyroid carcinoma/systemic immune- inflammation index/neutrophil- to- lymphocyte ratio/platelet-to-lymphocyte ratio/differential diagnosis分类
医药卫生引用本文复制引用
赵跃,郭永刚,孙甲甲,刘春蓉,周广磊,黄景昊,王宁,吴凤云..术前SII、NLR、PLR在分化型甲状腺癌中的诊断价值分析[J].兰州大学学报（医学版）,2018,44(6):50-56,7.基金项目
国家自然科学基金项目(81302577) （81302577）
