兰州大学学报（医学版）2018，Vol.44Issue(6)：70-75,6.DOI:10.13885/j.issn.1000-2812.2018.06.013
太赫兹技术在检测蛋白质类有机化合物的应用进展
Application of terahertz technology in detecting protein organic compounds
摘要
Abstract
Terahertz technology is based on the far-infrared spectroscopy measurement that detects terahertz (THz) waves. In recent years, its applications in medical research, food testing, and biological research have progressed rapidly. Combined with an introduction of the characteristics of the THz technology, the review described the progress made in the use of THz technology in the structure, conformation, dynamics and quantitative detection of amino acids, peptides, and proteins. A comparison was made of the absorption peaks of the same amino acids and peptides in the THz band determined under different experimental conditions. Applications were explored in the study of qualitative and quantitative analysis of mixed amino acids, THz spectra of amino acid aqueous solutions, the reasons for the differences in the THz spectra of different amino acids. Protein conformation, conformation and kinetics of protein solutions, antigen-antibody interactions and protein quantification were researched. A preliminary exploration was made of the development prospects and its urgentproblem of this technology in the biomedical field.关键词
太赫兹/氨基酸/肽/蛋白质Key words
terahertz/amino acid/peptide/protein分类
医药卫生引用本文复制引用
谢明真,蒋丽云,车团结,何津春..太赫兹技术在检测蛋白质类有机化合物的应用进展[J].兰州大学学报（医学版）,2018,44(6):70-75,6.基金项目
国家重点基础研究发展计划项目(973计划)(2015CB755402) （973计划）
甘肃省中医药管理局科研项目(GZK-2017-50) （GZK-2017-50）
甘肃省戒毒管理局项目(2014-2) （2014-2）
甘肃省自然科学基金项目(1308RJZA218),甘肃省功能基因组与分子诊断重点实验室开放项目(2016-005) （1308RJZA218）
甘肃省科技重大专项计划项目(1302FKDA034) （1302FKDA034）
兰州大学第一临床医学院卓越计划项目(20180060154) （20180060154）
