临床肝胆病杂志2018，Vol.34Issue(1)：35-38,4.DOI:10.3969/j.issn.1001-5256.2018.01.007
推荐使用统一ALT判断值时应重视的医学检验问题
The medical laboratory issues about recommendation on uniform cutoff values of "normal" ALT in the ACG guidelines
摘要
Abstract
In the recent American clinical guidelines dealing with laboratory tests for evaluation of liver disease, the American College of Gastroenterology (ACG) recommends ALT upper reference limits of 33 U/L for males and 25 U/L for females respectively, and that individuals with ALT above these"normal"cutoffs should be further investigated. Considering the differences between laboratory assays measuring ALT in our country, the standardization of methods and the consistency of results can not be completely ensured. The uniform "normal"range of ALT recommended by the ACG guidelines is largely based on findings from foreign studies and may not be suitable to Chinese population. On the other hand, reference upper/lower limits should not simply be equated with clinical decision thresholds. However, due to improper application of the related concepts of the above medical laboratory issues, simply recommending the uniform reference range of the ALT may lead to overdiagnosis and unnecessary follow-up examinations.关键词
肝功能试验/丙氨酸转氨酶/争鸣Key words
liver function test/alanine transaminase/contending分类
医药卫生引用本文复制引用
虞倩,潘柏申..推荐使用统一ALT判断值时应重视的医学检验问题[J].临床肝胆病杂志,2018,34(1):35-38,4.基金项目
上海市卫生计生系统重要薄弱学科建设项目(2015ZB0201) （2015ZB0201）
