马佳丽 1李坪 1魏红山 1周玉玲 1梁秀霞 1胡居龙 1艾正琳 1陈旭1
作者信息
- 1. 首都医科大学附属北京地坛医院, 北京 100015
- 折叠
摘要
Abstract
Objective To investigate the risk factors for glue extrusion bleeding after endoscopic tissue adhesive injection for the treatment of esophagogastric variceal bleeding. Methods A total of 416 patients with liver cirrhosis complicated by esophagogastric variceal bleeding or a past history of bleeding who were admitted to Beijing Ditan Hospital, Capital Medical University, from October 2008 to January 2016 were enrolled. A retrospective analysis was performed for their clinical data, including sex, age, etiology, routine blood test results, hepatic and renal function, electrolytes, blood lipids, coagulation, diameter of the portal vein, anteroposterior diameter of the spleen, Child-Pugh score, and volume of tissue adhesive injection. The t-test was used for comparison of continuous data between groups, and a multivariate logistic regression analysis was also performed. Results Of all patients, 59 experienced glue extrusion bleeding, resulting in an incidence rate of 14. 18％ . The univariate analysis showed that there were significant differences in total bilirubin, direct bilirubin, total bile acid, Child-Pugh score, and volume of tissue adhesive injection between the patients with glue extrusion bleeding and those without (t = 2. 54, 2. 85, 2. 35, 1. 03, and 4. 38, all P ＜ 0. 05) . The multivariate logistic regression analysis showed that Child-Pugh score (odds ratio[OR]= 2. 714, 95％ confidence interval[CI]1. 600-4. 850, P = 0. 009) and volume of tissue adhesive injection (OR = 2. 925, 95％ CI 1. 762-5. 124, P = 0. 008) were independent risk factors for glue extrusion bleeding. Conclusion Patients with higher Child-Pugh score and volume of tissue adhesive injection tend to have a higher risk of glue extrusion bleeding.关键词
肝硬化/食管和胃静脉曲张/出血/危险因素Key words
liver cirrhosis/esophageal and gastric varices/hemorrhage/risk factors分类
医药卫生
