临床肝胆病杂志2018，Vol.34Issue(1)：192-194,3.DOI:10.3969/j.issn.1001-5256.2018.01.042
肝星状细胞通过TGFβ1-PI3K/AKT信号通路影响肝硬化-肝细胞癌癌前病变的研究进展
Research advances in the influence of hepatic stellate cells on precancerous lesions of liver cirrhosis and hepatocellular carcinoma via the TGFβ1-PI3K/AKT signaling pathway
摘要
Abstract
The malignant transformation of the precancerous lesions of liver cirrhosis and hepatocellular carcinoma (HCC) leads to the formation of liver cancer. Hepatic stellate cells (HSCs) play a role in the production of cells in precancerous lesions of HCC, the formation of hepatic fibrosis microenvironment, and the interaction between them via the TGFβ1-PI3 K/AKT signaling pathway. An understanding of the mechanism for the malignant transformation of the precancerous lesions of liver cirrhosis and HCC and the association between HSCs and the TGFβ1-PI3 K/AKT signaling pathway helps to investigate the pathogenesis of HCC. Regulation of HSCs or intervention of the TGFβ1-PI3 K/AKT signaling pathway can inhibit or reverse the progression of liver cirrhosis to HCC, which provides new thoughts and therapeutic targets for prevention and intervention of the development of HCC.关键词
肝硬化/癌,肝细胞/癌前状态/肝星状细胞/信号传导/综述Key words
liver cirrhosis/carcinoma, hepatocellular/precancerous conditions/hepatic stellate cell/signal transduction/review分类
医药卫生引用本文复制引用
鞠迪,李京涛,韩曼,魏海梁,闫曙光,李汨,史晓燕,常占杰..肝星状细胞通过TGFβ1-PI3K/AKT信号通路影响肝硬化-肝细胞癌癌前病变的研究进展[J].临床肝胆病杂志,2018,34(1):192-194,3.基金项目
国家自然科学基金(81603612) （81603612）
陕西省科技厅(2012SF2-11,2014K11-02-04-06,2016SF-234) （2012SF2-11,2014K11-02-04-06,2016SF-234）
陕西省中医药管理局(15-JC009,JCPT037) （15-JC009,JCPT037）
北京医学奖励基金会课题(YJHYXKYJJ-276) （YJHYXKYJJ-276）
陕西中医药大学自然科学创新基金项目(2017SZKY-037) （2017SZKY-037）
