临床神经外科杂志2019，Vol.16Issue(4)：290-294,5.DOI:10.3969/j.issn.1672-7770.2019.04.003
TERTp和1p/19q对顺铂联合替莫唑胺同期放化疗治疗MGMT启动子未甲基化GBM的预后影响
Prognostic value of TERTp and 1p／19q in cisplatin combined with temozolomide concurrent chemoradiotherapy for newly diagnosed GBM with unmethylated MGMT promoter
摘要
Abstract
To investigate the clinical characteristics and prognostic value of TERTp and 1p／19q phenotype in DDP +TMZ concurrent chemoradiotherapy for newly diagnosed GBM with unmethylated MGMT promoter.Methods A retrospective analysis was made in 73 newly diagnosed GBM with unmethylated MGMT promoter.All patients received DDP+TMZ.The aim of this study was to analyze the clinical characteristics , adverse reactions, PFS and OS of patients with different TERTp and 1p／19q groups.Results According to TERTp, there were 30 cases of TERTp wt and 43 cases of TERTp mut.According to 1p／19q, 62 cases were non-deletion and 11 cases were deletion.There was no significant difference in clinical parameters between two groups (P＞0.05). Up to 31st January 2019, 44 patients had recurrence , 17 with TERTp wt and 27 with TERTp mut. The median PFS was 12.0 and 10.0 months, respectively.The 1-year PFS rate was 33.6% and 27.2%.22 patients died, 9 with TERTp wt and 13 with TERTp mut.The median OS was 20.0 and 19.0 months.The 1-year OS rate was 77.9% and 73.2%.There were 38 recurrences in 1p／19q non-deletion and 6 recurrences in deletion.The median PFS was 10.0 and 22.0 months respectively.The 1-year PFS rate was 20.4%and 60.0%.There were 19 deaths with 1p／19q non-deletion, 3 deaths in deletion, and the median OS was 18.0 and 23.0 months.The 1-year OS rates were 60.3%and 88.9%.There was a better trend in the efficacy for 1p／19q non-deletion than that of deletion.But the difference was not significant.Conclusion The efficacy of TERTp wt is slightly higher than that of TERTp mut.The efficacy of 1p／19q deletion group is higher than that of non-deletion, but the difference is not statistically significant.1p／19q may have potential prognostic value in newly diagnosed GBM with unmethylated MGMT promoter receiving DDP +TMZ concurrent chemoradiotherapy, which deserves further study.关键词
胶质母细胞瘤/O6-甲基鸟嘌呤-DNA甲基转移酶启动子未甲基化/端粒酶逆转录酶/1p／19q/顺铂/替莫唑胺Key words
glioblastoma/unmethylated MGMT promoter/TERT/1p/19q/cisplatin/temozolomide分类
医药卫生引用本文复制引用
高洪元,胡莉,王宝红,张玺炜,汪洋,盛晓芳,吴学勇,殷晓峰,陈淑,倪春霞,孟歌..TERTp和1p/19q对顺铂联合替莫唑胺同期放化疗治疗MGMT启动子未甲基化GBM的预后影响[J].临床神经外科杂志,2019,16(4):290-294,5.基金项目
上海市科学技术委员会医学引导类西医科技支撑项目(16411972300) （16411972300）
