肿瘤预防与治疗2019，Vol.32Issue(6)：486-493,8.DOI:10. 3969/j. issn. 1674-0904. 2019. 06. 003
免疫检查点分子在子宫内膜癌中的表达及临床意义
Expression of Immune Checkpoint Molecules in Endometrial Carcinoma and Its Clinical Significance
张丽萍 1林雪萍 1宋辉 1雷萍 1朱巧英1
作者信息
- 1. 610045 成都,四川省妇幼保健院检验科
- 折叠
摘要
Abstract
Immune checkpoint inhibitor treatment is effective in several solid tumors, but they have not been widely used in endometrial carcinoma (EC). Previous studies have shown that programmed death protein-1 (PD-l)/programmed death pro-tein-ligand 1 (PD-Ll) is significantly elevated in POLE mutant EC and EC with MSI, while the expression of other immune checkpoint molecules is not yet clearly known. The purpose of this study is to comprehensively analyze the expression of various immune check-point molecules in EC and its clinical significance. Methods: By analyzing the EC data in TCGA database, this study investigated the relationship between various immune checkpoint molecules and EC molecular subtypes, pathological types and prognosis of patients. Results: First, we used exon sequencing and RNA sequencing data to classify molecular subtypes of EC. The classification results were consistent with previous studies. We found that the immune checkpoint molecules, PD-l/PD-Ll, CTLA-4/CD80 and LAG-3/FGLl, were highly expressed in POLE mutant EC and EC with MSI. FGLl was highly expressed in MSI and no specific molecular profile sub-types. High expression of PD-l, CTLA-4, TIM-3 and LAG-3 was associated with prolonged overall survival. High-expression of FGLl was significantly associated with prolonged overall survival and relapse-free survival, while other ligands were not significantly associat- ed with prognosis. FGLl was highly expressed in endometrioid carcinomas, and the expression of FGLl was relatively low in serous or mixed tumors. FGLl was not significantly correlated with the abundance of various lymphocytes and macrophages, suggesting that FGLl may be expressed by cancer cells. In addition, the tumor mutation burden was significantly higher in FGLl-high tumors than in FGLl-low tumors. Conclusion: In addition to PD-l/PD-Ll, other immunosuppressive pathways (especially LAG-3/FGLl) are dysregulated in EC, which suggests novel potential strategies for EC immunotherapy.关键词
子宫内膜癌/免疫治疗/免疫检查点/PD-1/FGL1Key words
Endometrial carcinoma/Immunotherapy/Immune checkpoint/ PD-1/ FGL1分类
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张丽萍,林雪萍,宋辉,雷萍,朱巧英..免疫检查点分子在子宫内膜癌中的表达及临床意义[J].肿瘤预防与治疗,2019,32(6):486-493,8.
