摘要
Abstract
To evaluate the value of serum procalcitonin (PCT) level in the differential diagnosis of infection and can-cerous fever of patients with malignant tumor. Methods: We retrospectively collected clinical and laboratory data of 140 patients with lung cancer who underwent PCT detection in Qingdao NO. 9 People's Hospital from January 2013 to October 2018. The patients were divided into four groups: the infection with fever group, the infection without fever group, the cancerous fever without infection group and the non infection without fever group. Level of PCT in four groups were compared, and receiver operating characteristic curve was drawn to evaluate the value of PCT in differential diagnosis in lung cancer infection and cancerous fever. Results: The serum PCT level of small cell lung cancer patients was higher than that of non-small cell lung cancer patients (4. 322 us 0. 142; Z = -4. 240, P<0.001); the serum PCT level of patients with metastasis was higher than that of patients without metastasis (0.609 us 0.111; Z=-2.517, P=0.006). The serum PCT level was 0. 652 (0. 290~1. 147) ug/L in the infection with fever group, 0.439 (0. 174~1. 074) ug/L in the cancerous fever without infection group, 0.378 (0. 117~0. 581) ug/L in the infection without fever group, and 0.126 (0.038~0. 451) ug/L in the non infection without fever group. The best cut-off point of PCT for diagnosis of lung cancer was 0.349 ug/L, the area under the curve was 0. 645 ± 0. 043, and the sensitivity and specificity were 0. 449 and 0. 769, respectively. The best cut-off point of PCT for diagnosis of infection without fever in lung cancer patients was 0. 098 ug/L, and the area under the curve was 0.678 ± 0. 051. The sensitivity and specificity were 0. 518 and 0. 763, respectively. The best cut-off point of PCT for diagnosis of infection with fever in lung cancer patients was 0.954 ug/L, and the area under the curve was 0.704 ± 0.074. The sensitivity and spe-cificity were 0. 341 and 0. 939, respectively. Conclusion: Serum PCT, as a rapid, simple and easily available laboratory diagnostic index, can be used as a reference for the diagnosis of infection in patients with lung cancer fever. However, elevated serum PCT level does not always mean infection.关键词
降钙素原/癌性发热/感染/鉴别诊断/应用价值Key words
Procalcitonin/Cancerous fever/Infected/ Differential diagnosis/ Application value分类
医药卫生
